Abstract：Objective: To investigate the efficacy of topaplatin combined with nesiritide in the treatment of acute heart failure (AHF) and its effect on the levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), troponin T (cTnT) and soluble ST2 (sST2). Methods: 200 patients with AHF were randomly divided into the control group (n = 100, nesiritide) and the observation group (n = 100, tovapritide + nesiritide) according to the method of residues of random number table. The clinical efficacy, ventricular remodeling, serum NT-proBNP, cTnT, sST2 expression and safety were compared between the two groups. Results: The total effective rate of the observation group was 93.00%, which was higher than that of the control group (82.00%) (P<0.05). The changes of left ventricular end-systolic volume index (LVESVI), left ventricular end-diastolic volume index (LVEDVI) and left ventricular mass index (LVMI) in the observation group were significantly higher than those in the control group before and after treatment. The changes of serum NT-proBNP, cTnT and sST2 levels in the observation group before and after treatment were significantly higher than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was 6.00%, which was lower than that in the control group (15.00%) (P<0.05). Conclusion: Tovaptan combined with nesiritide is superior to nesiritide in the treatment of AHF. It can not only delay ventricular remodeling, but also reduce the expression of serum NT-proBNP, cTnT and sST2 and reduce the incidence of adverse reactions.
孙维, 菅志飞, 张继勇. 托伐普坦联合奈西立肽治疗急性心力衰竭的疗效及对NT-proBNP cTnT sST2水平的影响[J]. 河北医学, 2021, 27(5): 873-877.
SUN Wei, JIAN Zhifei, et al. Efficacy of Tolvastan Combined with Nesiritide in the Treatment of Acute Heart Failure and Its Effect on The Levels of NT-proBNP cTnT and sST2. HeBei Med, 2021, 27(5): 873-877.
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2021, Vol. 27 
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