Abstract：Objective: To explore the efficacy of intermittent positive pressure ventilation (IPPV) combined with pulmonary surfactant (PS) in the treatment of neonatal respiratory distress syndrome (NRDS). Methods: The data of 153 NRDS patients were analyzed retrospectively from December 2017 to December 2019. All the children were treated with IPPV, and the children with PS were included in the study group (n = 82 cases), while those without PS treatment were included in the control group (n=71). The curative effect, related treatment, arterial blood gas analysis indexes before and after treatment, incidence of adverse reactions, and lung function indexes during follow-up were compared between the two groups. Results: The total response rate in the study group was significantly higher than that in the control group (96.34% vs 84.51%) (P<0.05). The oxygen therapy time, ventilation time, treatment costs and hospital stay of the study group were significantly shorter and lower than those of the control group (P<0.05). After treatment, the arterial partial pressure of carbon dioxide (PaCO2), oxygenation index (OI), arterial partial pressure of oxygen (PaO2), and blood oxygen saturation (SpO2) were significantly improved (P<0.05). And the improvement in the study group was significantly greater than that in the control group (P<0.05). The incidence of bronchopulmonary dysplasia was significantly lower in the study group than in the control group (P<0.05). The study group had lower respiratory rate than the control group, and the tidal volume, volume to peak tidal expiratory flow and time to peak were significantly larger and longer than the control group (P<0.05). Conclusion: Applying iPPV combined with PS in the treatment of NRDS can significantly improve the arterial blood gas analysis indexes in children, and shorten the time of treatment, with significant therapeutic effects.
2021, Vol. 27 
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