Abstract：Objective: To observe the expression levels of serum soluble CD40 ligand (sCD40L), tumor necrosis factor α (TNF-α) and matrix metalloproteinase 9 (MMP-9) in patients with chronic obstructive pulmonary disease (COPD) and analyze their significance. Methods: 82 patients with COPD were selected and divided into acute exacerbation group (n = 46) and clinical remission group (n = 36) according to the clinical staging. Meanwhile, 40 healthy people were made the control group. The expression levels of serum sCD40L, TNF-α and MMP-9 and lung function indexes [forced expiratory volume in 1s (FEV1), forced vital capacity (FVC), FEV1/FVC, the percentage of FEV1 in predicted value (FEV1%)] were compared among the 3 groups, and correlation analysis was performed. Results: The order of expression levels of serum sCD40L, TNF-α and MMP-9 in the 3 groups from high to low was as follows: the acute exacerbation group, the clinical remission group, the control group (P<0.017). The order of FEV1, FVC, FEV1/FVC and FEV1% in the 3 groups from low to high was as follows: the acute exacerbation group, the clinical remission group, the control group (P<0.017). Serum sCD40L, TNF-α and MMP-9 levels were negatively correlated with lung function (FEV1/FVC, FEV1%) in patients with COPD (P<0.05). Conclusion: The expression levels of serum sCD40L, TNF-α and MMP-9 in patients with COPD show an increasing trend, especially in patients with acute exacerbation. The higher the sCD40L, TNF-α and MMP-9 levels, the worse the lung function. The detection of the three indexes can provide an effective basis for the evaluation of COPD.
符英, 蔡晓玉, 钟巧, 魏华华, 常越. COPD患者血清sCD40L TNF-α及MMP-9水平及意义[J]. 河北医学, 2021, 27(5): 746-751.
FU Ying, CAI Xiaoyu, ZHONG Qiao, et al. Serum Levels and Significance of SCD40L TNF-α and MMP-9 in Patients with COPD. HeBei Med, 2021, 27(5): 746-751.
2021, Vol. 27 
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