Abstract：Objective: To investigate the expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene in lung cancer tissue and its relationship with pathological characteristics and prognosis.Methods: The clinical pathological data and follow-up data of 81 patients with lung cancer who were admitted to the hospital between January and December 2017 were retrospectively analyzed. Paraffin-embedded lung cancer tissues and adjacent tissues (about 2 cm from the edge of the cancer tissue) were collected from all the subjects. Immunohistochemical staining of CDKN2A in lung cancer and its adjacent tissues was observed. The relative expression levels of CDKN2A mRNA and CDKN2A protein in lung cancer and its adjacent tissues were compared. According to the expression level of CDKN2A in lung cancer, the subjects were divided into the high expression group and the low expression group. The two-year follow-up survival rate was compared between the two groups. Results: The expression rate of CDKN2A in lung cancer tissues was significantly lower than that in adjacent tissues (P<0.05). The relative expression levels of CDKN2A mRNA and CDKN2A protein in lung cancer tissues were significantly lower than those in adjacent tissues (P<0.05). The high expression rates of CDKN2A in patients with high differentiation degree and without lymph node metastasis were significantly higher than those with low differentiation degree and lymph node metastasis (P<0.05). The follow-up results showed that the 2-year survival rate of the high expression group [100.00% (8/8)] was significantly higher than that of the low expression group [65.67% (44/67)] (Log rank test value = 5.024, P<0.05). Conclusion: The expression of CDKN2A gene is low in lung cancer tissues, and its expression is closely related to the pathological characteristics and prognosis of patients with lung cancer, which can provide a reference for early diagnosis and treatment of lung cancer.
周晓瑜, 常杰, 王二晓, 张静静, 樊蕊. CDKN2A基因在肺癌组织中表达及其临床意义[J]. 河北医学, 2021, 27(4): 654-659.
ZHOU Xiaoyu, CHANG Jie, WANG Erxiao, et al. Expression of CDKN2A Gene in Lung Cancer and Its Clinical Significance. HeBei Med, 2021, 27(4): 654-659.
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2021, Vol. 27 
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