Abstract：Objective: To investigate the correlation between serum 25 (OH) vitamin D3 (VD3) levels and peripheral neuropathy (DPN) of patients with type 2 diabetes, and to analyze the related influencing factors of DPN.Methods: A total of 135 type 2 diabetes inpatients in the Aviation General Hospital from January 2018 to January 2019 were collected as research subjects. One group included 57 cases of diabetes without type 2 peripheral neuropathy (NDPN), and the other group included 78 patients of diabetes mellitus combined with type 2 peripheral neuropathy (DPN). The clinical data of all subjects for were collected for analysis, the HbA1c, FBG, PBG, Cr, ALT, LDL-C, and VD3 levels of the tested patients were measured, the proportion of the lack of VD3 levels in the NDPN group and the DPN group were counted, and VD3 level of patients in the two groups was compared. Logistic regression was used to analyze the independent risk factors of patients with DPN, and the possible causes of DPN were preliminarily discussed. Results: There was a certain difference in the course of disease and the level of glycosylated hemoglobin between the DPN group and the NDPN group (P<0.05). The average serum VD3 level in the DPN group was (24.55±11.27) ng/ml, and the level in the NDPN group was (50.43±18.48) ng/ml. The VD3 level in the DPN group was lower than that in the NDPN group (P<0.05). 93.6% of the patients in the DPN group had VD3 deficiency, 22.8% of NDPN patients had VD3 deficiency, and the proportion of VD3 deficiency in the DPN group was higher (P<0.05). Regression analysis showed that the course of disease and VD3 are independent risk factors for DPN. Conclusion: VD3 deficiency is relatively common in patients with DPN. In addition, VD3 deficiency is related to the occurrence of DPN. The occurrence and progression of DPN is related to VD3 deficiency.
2021, Vol. 27 
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