Abstract：Objective: To explore the effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor-evolocumab on blood lipid profiles and vascular endothelial function in patients with acute coronary syndrome (ACS). Methods: A total of 160 ACS patients in the hospital from June 2019 to June 2020 were enrolled and divided into observation group and control group by random number table method,80 cases in each group. The control group was given oral atorvastatin,while observation group was given subcutaneous injection of evolocumab on basis of control group. The levels of blood lipid profiles,vascular endothelial function,inflammatory factors and adverse reactions were compared between the two groups. Results: The difference values of cholesterol (TC),triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) before and after treatment in observation group were greater than those in control group (P<0.05),and difference values of serum endothelin 1 (ET-1) and nitric oxide (NO) before and after treatment were greater than those in control group (P<0.05). The difference values of serum inflammatory factors such as tumor necrosis factor α (TNF-α),interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) before and after treatment in observation group were greater than those in control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: PCSK9 inhibitor-evolocumab can effectively regulate blood lipid level of ACS patients,improve vascular endothelial function and inhibit inflammation reactions,with high medication safety.
林智海, 王正东, 李平, 吴梓嘉, 高露兰. PCSK9抑制剂-依洛尤单抗对急性冠状动脉综合征患者血脂谱及血管内皮功能的影响[J]. 河北医学, 2021, 27(3): 508-512.
LIN Zhihai, WANG Zhengdong, LI Ping, et al. Effects of PCSK9 Inhibitor-Evolocumab on Blood Lipid Profiles and Vascular Endothelial Function in Patients with Acute Coronary Syndrome. HeBei Med, 2021, 27(3): 508-512.
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2021, Vol. 27 
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