Abstract：Objective: To explore the levels of serum interleukin-10 (IL-10) and CXC chemokine ligand 16 (CXCL16) in patients with acute coronary syndrome (ACS) and its clinical significance. Methods: A total of 150 patients with ACS admitted to our hospital from June 2018 to June 2019 were selected as study objects (ACS group), who were divided into acute myocardial infarction group (AMI group, n=79) and unstable angina pectoris group (UAP group, n=71) according to the disease type. Also, the patients were divided into mild lesion group (n=65), moderate lesion group (n=52) and severe group (n=33) according to Gensini score. And the patients were divided into single vessel lesion group (n=60), double vessel lesion group (n=58) and triple vessel lesion group (n=32) according to the number of coronary artery lesions. At the same time, 60 patients with stable angina pectoris (SAP group) and 60 healthy volunteers (control group) were randomly selected as controls. The serum IL-10 and CXCL16 levels were detected by enzyme-linked immunosorbent assay. Results: The levels of IL-10 and CXCL16 in ACS group were higher than those in SAP group and control group (P<0.05). The level of IL-10 and CXCL16 in AMI group were higher than those in UAP group (t=9.186, 6.643; P<0.05). With the severity and number of coronary lesions in ACS group, the IL-10 and CXCL16 increased (P<0.05). The serum IL-10 in ACS group was positively associated with the Gensini scores and the number of coronary lesions (r=0.692, 0.702; P<0.05), and the CXCL16 was positively associated with the Gensini scores and the number of coronary lesions (r=0.637, 0.645; P<0.05). The ROC curve analysis showed that IL-10 and CXCL16 have differential diagnostic value for AMI and UAP, and the combined detection of both IL-10 and CXCL16 have a higher differential diagnostic value. The AUC was 0.860 (95%CI: 0.835~0.907), the sensitivity and specificity were 89.67% and 82.39%, and the accuracy was 86.34%. Conclusion: The up-regulation of serum IL-10 and CXCL16 are involved in the pathogenesis of ACS, which are closely related to the Gensini score of coronary lesions and the number of coronary lesions. Early detection of both IL-10 and CXCL16 can be used as important biochemical indexes for clinical differential diagnosis of ACS and assessment of the severity of coronary lesions.
马伟利, 蔡颖, 宝凤梅, 张凤梅, 张莉莉. 急性冠脉综合征患者血清中白细胞介素-10 CXC趋化因子16水平变化及其意义[J]. 河北医学, 2021, 27(2): 254-259.
MA Weili, CAI Ying, BAO Fengmei, et al. Levels of Serum IL-10, CXCL16 in Patients with Acute Coronary Syndrome and Its Clinical Significance. HeBei Med, 2021, 27(2): 254-259.
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2021, Vol. 27 
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