Abstract：Objective: To observe the clinical efficacy of Endo combined with liposomal paclitaxel and cisplatin in the treatment of liver metastases from lung cancer. Methods: A total of 125 patients with non-small cell lung cancer (NSCLC) who were admitted to our hospital from January 2018 to December 2019 and were treated with chemotherapy were randomly divided into observation group and control group based on the random number table. In the observation group, 67 cases were treated with "Endo + liposomal paclitaxel + cisplatin"; in the control group, 58 cases were treated with "liposomal paclitaxel + cisplatin". The clinical efficacy of the primary lesions and liver metastases were compared between the two groups, and the occurrence of adverse reactions in the two groups was recorded at the same time, and the two groups were followed up for more than 1 year to record the progression-free survival (PFS). Results: In terms of the efficacy of primary lung lesions, there was no significant difference in overall efficacy, ORR and DCR between the two groups (P>0.05). In terms of the efficacy of liver metastases, compared with the control group, the observation group has better overall clinical efficacy (P<0.05); the observation group has significantly higher ORR (38.81% vs 20.69%) and DCR (85.07% vs 68.97%) (P<0.05). Compared with the control group, the PFS of the observation group was significantly longer (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: Compared with the "liposomal paclitaxel + cisplatin" treatment, Endo combined with liposomal paclitaxel and cisplatin in the clinical treatment of lung cancer liver metastasis is more effective, and effectively inhibits liver metastasis, and it also significantly improves patients progression-free survival, improvs the prognosis of patients, and has clinical application value.
杨丽, 黄珣, 谢健. 恩度联合脂质体紫杉醇及顺铂治疗肺癌肝转移的疗效观察[J]. 河北医学, 2020, 26(12): 2080-2082.
YANG Li, HUANG Xun, XIE Jian. Efficacy of Endo Combined with Liposome Paclitaxel and Cisplatin in the Treatment of Liver Metastases from Lung Cancer. HeBei Med, 2020, 26(12): 2080-2082.
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2020, Vol. 26 
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