Abstract:Objective: To explore the ultrasonographic features and misdiagnosis of nodular cystic goiter. Methods: A retrospective analysis was performed on 64 patients admitted to our hospital from January 2016 to June 2020 who were misdiagnosed by pre-operative ultrasound as thyroid adenoma and other thyroid sarcoidosis and diagnosed by post-operative pathological examination as nodular goiter cystic degeneration. Sixty-four patients with nodular cystic goiter were selected as the observation group, and 24 patients with thyroid adenoma diagnosed by ultrasound and pathology were selected as the control group. The ultrasonographic features of patients with nodular goiter, the comparison of ultrasonographic findings between nodular goiter cystic degeneration and thyroid adenoma, and the ultrasonographic features of patients with nodular goiter who were misdiagnosed as other thyroid nodular lesions were analyzed. Results: The ultrasonographic images of nodular goiter cystic variable nodules were mainly characterized by clear boundaries, complete nodules, mostly enveloped, and no halo. Compared with thyroid tumor, there was no significant difference between the two lesions (P>0.05).There were significant differences in envelop, echo and halo between the two groups (P<0.05).The ultrasonographic features are similar to those misdiagnosed as other thyroid diseases. Conclusion: The ultrasonographic images of nodular cystic goiter are complex and diverse, and the main reasons for misdiagnosis are the lack of understanding of the complex and diverse echogenicity of nodular cystic goiter and the unclear analysis of thyroid nodule capsule, echo, halo and other aspects. Moreover, they are often misdiagnosed as thyroid adenoma.
[1] 周超.甲状腺腺叶切除术治疗63例结节性甲状腺肿的临床分析[J].实用临床医药杂志,2018,22(24):102~104. [2] Riguetto Cinthia Minatel,Miguel Vivian Peraro,Joao Pavin Elizabeth,et al. Fixed 30 mCi 131I-iodine therapy without recombinant human thyroid-stimulating hormone stimulation as an attractive therapeutic alternative in nontoxic nodular goiter.[J]. Nucl Med Commun,2020,11(5):1256~1260. [3] Chen Jianguo,Ma Zhiqiang,Yu Jianchun. Diagnostic pitfalls in a cystic ectopic intrathyroidal parathyroid adenoma mimicking a nodular goiter: A care-compliant case report.[J]. Medicine,2019,98(5):632~637. [4] A. Molinaro P,Orlandi F,Niccolai,et al. Tonacchera. Genetic interaction analysis of VEGF -A rs3025039 and VEGFR-2 rs2071559 identifies a genetic profile at higher risk to develop nodular goiter[J].Endocrinol Invest,2020,43(6):1302~1306. [5] Kravchenko Victor I,Andrusyshyna Iryna M,Luzanchuk Ihor A,et al. Association between thyroid hormone status and trace elements in serum of patients with nodular goiter.[J]. Biol Trace Elem Res,2019, 21(7):632~636. [6] 宋青,田晓琦,兰雨,等.常规超声联合超声造影诊断部分囊性甲状腺结节良恶性的价值[J].中国医学影像学杂志,2020,28(3):189~193. [7] 姚灵生,董艳霞.彩色多普勒超声联合CT诊断结节性甲状腺肿合并甲状腺癌的临床价值[J].医学影像学杂志,2019,29(2):323~326. [8] 王延海,杨华,郭宝生.囊实性甲状腺癌与结节性甲状腺肿囊性变的超声鉴别诊断[J].中国医科大学学报,2016,45(11):1031~1034. [9] 闫妍,苗立英,梅放,等.结节性甲状腺肿伴瘢痕形成易误诊为甲状腺乳头状癌的原因分析[J].中国超声医学杂志,2018,34(9):779~782. [10] Anat Bahat Dinur,Elhanan Quint,Liliana Lupo,et al. Limitations of ultrasound in predicting bilaterality vs unilaterality of well-differentiated carcinoma of the thyroid[J]. Otolaryngol-head N,2020,41(4):3214~3218.