Abstract：Objective: To explore the effects of early continuous blood purification (CBP) on inflammatory mediators and coagulation function in patients with sepsis.Methods: A total of 110 patients with sepsis admitted to our hospital from January 2019 to December 2019 were selected for the study and divided into treatment group (55 cases) and control group (55 cases) with simple random grouping and random number table methods.Control group was given routine treatment,and treatment group was given CBP on the basis of control group,and the two groups were treated for 1 w.Before and after treatment,the organ function indexes [lactic acid,creatinine,bilirubin],inflammatory mediators [tumor necrosis factor-α (TNF-α),serum procalcitonin (PCT) and C-reactive protein (CRP)] and coagulation function [prothrombin time (PT),thrombin time (TT),and activated partial thromboplastin time (APTT)] were compared between the two groups.Acute Physiology and Chronic Health Evaluation (APACHE II) and Sepsis-Related Organ Failure Assessment (SOFA) were used to assess the disease severity in the two groups,and the clinical outcomes and prognosis were compared between the two groups.Results: The decreases of lactic acid,creatinine and bilirubin in treatment group before and after treatment were greater than those in control group (P<0.05).The decreases of TNF-α,PCT and CRP in treatment group before and after treatment were greater than those in control group (P<0.05).The increases of PT,TT and APTT in treatment group before and after treatment were greater than those in control group (P<0.05).The decreases of scores of APACHE II and SOFA in treatment group before and after treatment were greater than those in control group (P<0.05).The ICU stay and ventilator ventilation time in treatment group were significantly shorter than those in control group,and the mortality rate within 28d and incidence rate of MODS were significantly lower than those in control group (P<0.05).Conclusion: CBP can significantly improve the prognosis of patients by regulating the inflammatory mediators levels and coagulation function in the treatment of sepsis.
谢天驰, 刘璇. 早期连续性血液净化治疗对脓毒症患者PCT及CRP水平的影响[J]. 河北医学, 2020, 26(11): 1882-1886.
XIE Tianchi, et al. Effects of Early Continuous Blood Purification on PCT and CRP Levels in Patients with Sepsis. HeBei Med, 2020, 26(11): 1882-1886.
2020, Vol. 26 
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