Abstract：Objective: Detection of irregular antibody and its titer in serum of pregnant women,To assess the risk of fetal and neonatal hemolytic disease due to maternal-infant Blood Group incompatibility.Methods: from 2015 to 2019, blood samples from 731 pregnant women with hemolytic disease of the newborn were collected, Abo and RH blood group systems are tested for blood group, and antibody titers are measured by indirect antiglobulin assay in test tubes, Objective: to analyze the correlation between the detection rate of Abo Blood Group System Antibody titer ≥64 and RH blood group system titer ≥32 and the incidence rate of neonatal diseases.Results: of the 731 blood samples from pregnant women and newborns suspected of neonatal hemolytic disease, The detection rate of ABO-hdfn (+) in Abo blood group system was 11.36% (83/731) , The detection rate of Rh-HDFN (+) in RH blood group system was 2.06% (15/731) , There were statistical differences (p < 0.05);Of the 98 high-risk HDFN pregnant women, 74 cases of hemolytic disease of the newborn, The incidence of HDFN was 75.51% (74/98) , and the higher the antibody titer, the higher the risk of HDFN, The prevalence of HDFN was highest when the titer of antibody was ≥1:128, The positive rate of 0 ~ 3 days after birth was significantly higher than 4 ~ 10 days after birth, There was significant difference (88.71% vs 52.78% p < 0.05).Conclusion: The detection rate of Abo Blood Group system is higher than that of RH blood group system, The highest number and detection rate of type O were found in pregnant women, and the prevalence rate was proportional to the value of antibody, The positive rate was higher when the samples were sent within 3 days after birth.
2020, Vol. 26 
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