Abstract：Objective: To establish the median equation of serum markers in prenatal screening in the early and middle pregnancy in Shijiazhuang area and explore the screening efficiency and clinical value of the localized median equation. Methods: We collected the screening data of the 28930 pregnant women in the first and second trimester from January 2017 to November 2018. The median values of PAPP-A, free hCGβ, AFP, uE3 and NT in both the software record and in local population were compared. Then the data were applied to the evaluation of the risk of Down's syndrome and compared the difference of the screening efficiency. Results: 1. The median concentrations of PAPP-A, free hCGβ, uE3 in Shijiazhuang were higher than those of Caucasian population. The difference was statistically significant(P<0.05). There was no significant difference in the median concentration of AFP between the local population and the Caucasian population(P>0.05). 2. There were significant differences between the MoM median of serum markers of local population and software median equation (P<0.05). 3. By using the median of local population, the high-risk rate of trisomy 21 was 2.33%. The detection rate of trisomy 21 was 94.59%. By using the software's built-in median, the high-risk rate of trisomy 21 was 2.16%. The detection rate of trisomy 21 was 86.48%. The difference was statistically significant(P<0.05). Conclusion: The medians of serum markers were significantly different between the population of Shijiazhuang and the Caucasus population. The application of the localized median can significantly improve the screening efficiency. For the development of Down's screening in Shijiazhuang, it is of great significance to establish the localized median database of serums markers in the first and second trimester of pregnancy.
米冬青, 宋歌, 彭园园, 孙东兰, 高虹, 张静. 早中孕期唐氏筛查血清标志物中位数方程的建立及其临床价值[J]. 河北医学, 2020, 26(10): 1727-1733.
MI Dongqing, SONG Ge, PENG Yuanyuan, et al. The Establishment and Clinical Value of Medians of Serum Markers in Down's Syndrome Prenatal Screening. HeBei Med, 2020, 26(10): 1727-1733.
2020, Vol. 26 
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