Abstract：Objective: To explore the relevance between long non-coding RNA (lnc RNA) CCHE1 expression and clinical features, prognosis of lung adenocarcinoma. Methods: Eighty-three patients with lung adenocarcinoma who underwent surgical resection from December 2015 to December 2016 were enrolled. The paraffin blocks of lung cancer tissues and adjacent normal tissues were collected. The expression of lnc RNA CCHE1 was detected by qRT-PCR. The relevance between its expression and clinicopathological features of patients were analyzed. The prognosis of patients was followed up. The value of lnc RNA CCHE1 expression in prognosis determining was analyzed. Results: The expression of lnc RNA CCHE1 in lung adenocarcinoma tissues was significantly higher than that in adjacent tissues (P<0.05). The expression of lnc RNA CCHE1 in patients with high TNM stage, lymph node metastasis and poor differentiation degree was significantly higher than that with low TNM stage, without lymph node metastasis and with high differentiation degree (P<0.05). AUC of lnc RNA CCHE1 for diagnosis of lung adenocarcinoma was 0.925 (95%CI: 0.876-0.974). When lnc RNA CCHE1 was not lower than 29.18, the sensitivity and specificity were 94.0% and 89.2%, respectively. 22 patients died and 61 survived. The expression of lnc RNA CCHE1 in the dead was (73.15 ± 8.45), which was significantly higher than that in the survivors(P<0.05). The 3-year progression-free survival (PFS) rate and overall survival rate in patients with high expression of lnc RNA CCHE1 were 32.84% (22/67) and 68.66% (46/67), which were significantly lower than those with low expression (P<0.05). TNM stage, lymph node metastasis, differentiation degree and lnc RNA CCHE1 level were independent factors affecting PFS and OS in patients with lung adenocarcinoma after 3 years of surgery (P<0.05). Conclusion: The expression of lnc RNA CCHE1 is increased in lung adenocarcinoma tissues. Its expression is relevant to clinicopathological features and prognosis of patients, which can be applied as a potential molecular marker of lung adenocarcinoma.
唐荣彬, 王刚. lncRNA CCHE1与肺腺癌临床特征及预后的关系研究[J]. 河北医学, 2020, 26(10): 1715-1720.
TANG Rongbin, WANG Gang. A Study of the Relevance Between lncRNA CCHE1 and Clinical Features Prognosis of Lung Adenocarcinoma. HeBei Med, 2020, 26(10): 1715-1720.
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2020, Vol. 26 
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