Abstract：Objective: To explore the correlation between serum homocysteine (Hcy) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) and clinical prognosis of patients with chronic heart failure (CHF). Methods: 70 cases of CHF patients admitted to department of cardiology of our hospital from January 2017 to March 2019 were included as observation group, and 70 healthy persons who came to the hospital for physical examination during the same period were selected as control group. The ultrasound detection indexes [left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD)] and serum Hcy and NT-pro-BNP levels were compared between the two groups. Spearman correlation analysis was used to analyze the correlation between serum Hcy and NT-pro-BNP and LVEF and LVEDD. Patients in observation group were treated with anti-heart failure therapy. The occurrence of major adverse cardiovascular events (MACE) were followed up within 1 year after discharge. According to the follow-up results, the patients were divided into MACE group and non-MACE group, and the serum Hcy and NT-pro-BNP levels were compared between the groups. Results: The LVEF of observation group was less than that of control group while the LVEDD and serum Hcy, NT-pro-BNP were significantly higher than those of control group (all P<0.05). Spearman correlation analysis showed that serum Hcy and NT-pro-BNP were negatively correlated with LVEF (r=-0.867,-0.892, all P<0.05), and were positively correlated with LVEDD (r= 0.812, 0.870, all P<0.05). Serum Hcy and NT-pro-BNP of MACE group were significantly higher than those of non-MACE group (all P<0.05). Conclusion: Serum Hcy and NT Pro BNP levels are closely related to cardiac function in patients with CHF, which can provide basis for predicting clinical prognosis.
海澜, 雷晓亭, 王鹏. 血清Hcy及NT-pro-BNP与慢性心力衰竭患者临床预后的相关性研究[J]. 河北医学, 2020, 26(10): 1712-1715.
HAI Lan, LEI Xiaoting, WANG Peng. Study on the Correlation between Serum Hcy and NT-pro-BNP and Clinical Prognosis of Patients with Chronic Heart Failure. HeBei Med, 2020, 26(10): 1712-1715.
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2020, Vol. 26 
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