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河北医学  2020, Vol. 26 Issue (10): 1642-1647    DOI: 10.3969/j.issn.1006-6233.2020.10.014
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DJ-1在前列腺癌中的表达及其与新辅助内分泌治疗疗效的关系分析
韦高猛, 唐毓金, 黄勇平
右江民族医学院附属医院泌尿外科, 广西 百色 533000
Expression of DJ-1 in Prostate Cancer and its Relationship with Curative Effect of Neoadjuvant Endocrine Therapy
WEI Gaomeng, TANG Yujin, HUANG Yongping
The Affiliated Hospital of Youjiang Medical College for Nationalities, Guangxi Baise 533000, China
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摘要 目的: 探讨DJ-1在前列腺癌中的表达及其与新辅助内分泌治疗疗效的关系。方法: 收集本院2015年1月~2016年4月98例穿刺确诊为前列腺癌患者的癌组织、癌旁新鲜组织,另选取良性前列腺增生患者前列腺增生组织蜡块98例。免疫组化技术检测各组织中DJ-1蛋白表达水平;检测前列腺癌患者经新辅助内分泌治疗前后的DJ-1蛋白表达水平。χ2检验分析DJ-1与前列腺癌临床病理参数及新辅助内分泌治疗疗效的关系;Kaplan-Meier生存曲线及Log-rank法检验DJ-1与无生化复发生存率的关系。结果: 前列腺增生组织的DJ-1蛋白表达量明显低于及前列腺癌组织,差异有统计学意义(P<0.05),而与癌旁组织组对比无统计学差异(P>0.05);且癌旁组织DJ-1蛋白表达量明显低于前列腺癌组织(P<0.05)。DJ-1在新辅助内分泌治疗后整体阳性表达情况下降,差异有统计学意义(P<0.05)。经比较,DJ-1阳性患者和阴性患者在Gleason分期、有无淋巴结转移、TNM分期及临床疗效方面差异有统计学意义(P<0.05)。DJ-1阴性(-)、弱阳性(+)、中度阳性(++)、强阳性(+++)组3年无生化复发生存率分别为93.33%、87.50%、74.07%、70.27%,经Log-rank检验组间差异具有统计学意义(P<0.05)。结论: DJ-1的表达与肿瘤分化程度、淋巴结转移、TNM分期、新辅助内分泌治疗临床疗效及3年无生化复发生存率相关,对于前列腺癌患者的预后有一定预测价值。
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韦高猛
唐毓金
黄勇平
关键词 前列腺癌新辅助内分泌治疗DJ-1免疫组化    
AbstractObjective: To explore the expression of DJ-1 in prostate cancer and its relationship with curative effect of neoadjuvant endocrine therapy. Methods: The cancer tissues and para-cancerous fresh tissues of 98 patients who were confirmed with prostate cancer by puncture in the hospital from January 2015 to April 2016 were collected. The paraffin blocks of benign prostatic hyperplasia (BPH) tissues from 98 BPH patients were collected. The expression level of DJ-1 protein in each tissue was detected by immunohistochemistry. The expression level of DJ-1 protein in prostate cancer patients before and after neoadjuvant endocrine therapy was detected. χ2 test was applied to analyze the relationship between DJ-1 and clinical pathological parameters of prostate cancer, curative effect of neoadjuvant endocrine therapy. Kaplan-Meier survival curve and Log-rank method were applied to detect the relationship between DJ-1 and biochemical recurrence-free survival (BRFS). Results: The expression level of DJ-1 protein in BPH tissues was significantly lower than that in prostatic cancer tissues (P<0.05). There was no significant difference in the above index between BPH tissues and para-cancerous tissues (P>0.05). The expression level of DJ-1 protein in para-cancerous tissues was significantly lower than that in prostatic cancer tissues (P<0.05). After neoadjuvant endocrine therapy, positive expression of DJ-1 was decreased (P<0.05). There were significant differences in Gleason staging, lymph node metastasis, TNM staging and clinical curative effect between patients with positive DJ-1 and negative DJ-1 (P<0.05). The 3-year BRFS rates in DJ-1 negative (-), weak positive (+), moderate positive (++) and strong positive (+++) group were 93.33%, 87.50%, 74.07% and 70.27%, respectively. The differences among all groups were statistically significant detected by Log-rank test (P<0.05). Conclusion: The expression of DJ-1 is associated with tumor differentiation, lymph node metastasis, TNM staging, clinical curative effect of neoadjuvant endocrine therapy and 3-year BRFS rate, which is of certain predictive value for prognosis of patients with prostate cancer.
Key wordsProstate cancer    Neoadjuvant endocrine therapy    DJ-1    Immunohistochemistry
    
基金资助:广西壮族自治区百色市科学研究与技术开发计划项目,(编号:20183328)
通讯作者: 唐毓金   
引用本文:   
韦高猛, 唐毓金, 黄勇平. DJ-1在前列腺癌中的表达及其与新辅助内分泌治疗疗效的关系分析[J]. 河北医学, 2020, 26(10): 1642-1647.
WEI Gaomeng, TANG Yujin, HUANG Yongping. Expression of DJ-1 in Prostate Cancer and its Relationship with Curative Effect of Neoadjuvant Endocrine Therapy. HeBei Med, 2020, 26(10): 1642-1647.
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