Abstract：Objective: To explore the prognostic factors and predictive value of thrombolytic patients with emergency cerebral infarction. Methods: The data of 248 patients with acute cerebral infarction treated by thrombolysis in hospital from August 2017 to August 2019 were analyzed and divided into poor prognosis group (n=104) and good prognosis group (n=144) according to the patients' neurological recovery. All patients received intravenous thrombolysis. The risk factors were observed and analyzed that may affect the prognosis of thrombolytic patients with emergency cerebral infarction, and perform multivariate logistic regression. And do some prognostic value analysis on the prognosis of some factors/indicators. Results: The results of univariate analysis showed that the onset-treatment time, incidence of diabetes history, homocysteine, blood glucose, and systolic blood pressure before intravenous thrombolysis in the poor prognosis group were significantly different from those in the good prognosis group (P<0.05) ; Multivariate regression results show that: onset-treatment time index, NIHSS index, previous diabetes history index, homocysteine index, blood glucose index, and systolic blood pressure index before intravenous thrombolysis are the significant factors affecting the poor prognosis of patients with acute cerebral infarction thrombolysis Influencing factors (P<0.05). Three of these indicators (homocysteine, blood glucose, and systolic blood pressure before intravenous thrombolysis) were analyzed by ROC, which showed that it had a certain predictive evaluation value for the prognosis of patients with acute cerebral infarction thrombolysis. The AUC (0.95CI) were: 0.749 (0.595~0.942), 0.783 (0.666~0.921), 0.678 (0.548-0.839). The combined application has a higher value in predicting the prognosis of patients with acute thrombolysis of cerebral infarction, and its AUC (0.95CI) is 0.819 (0.637~0.996). Conclusion: There are many independent risk factors that influence the prognosis of patients with acute cerebral infarction thrombolysis. Clinicians need to pay close attention to the onset-treatment time, NIHSS, previous medical history of diabetes, homocysteine, blood glucose, systolic blood pressure before intravenous thrombolysis and other factors.
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2020, Vol. 26 
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