Abstract：Objective: To investigate the expression of serum interleukin-17 (IL-17) and toll-like receptor 4 (TLR4) in patients with chronic obstructive pulmonary disease (COPD) and their correlation with the forced expiratory volume in the first second as a percentage of the predicted value (FEV1%pred), the modified British medical research council (mMRC grading), and the COPD Assessment Test (CAT) score.Methods: The levels of serum IL-17 and TLR4 in patients in three groups [COPD group, healthy smoking control group (C1), healthy non-smoking control group (C2), 80 cases in each group] were measured by ELISA method, and analyzed their relevance with FEV1%pred, mMRC grading, and CAT score. Results: The levels of serum IL-17 and TLR4 in patients of COPD group were significantly higher than those in health controls (C1 group and C2 group) (P<0.05). Serum IL-17 in group C1 was significantly higher than that in group C2 (P<0.05); serum TLR4 in group C1 was significantly lower than that in group C2 (P<0.05). The levels of serum IL-17 and TLR4 in the patients of COPD group were negatively correlated with FEV1%pred (P<0.05). The levels of serum IL-17 and TLR4 in COPD group were positively correlated with mMRC grading and CAT score (P<0.05). There was a positive correlation between the serum IL-17 level and TLR4 level in the patients of COPD group (P<0.05). Conclusion: The levels of IL-17 and TLR4 in patients with chronic obstructive pulmonary disease were significantly up-regulated, and they were positively correlated with the severity of the disease.
孙印, 韦海燕. 慢阻肺患者血清IL-17 TLR4水平与FEV1%pred mMRC分级及CAT评分的相关性[J]. 河北医学, 2020, 26(10): 1630-1633.
SUN Yin, WEI Haiyan. The Correlation of Serum IL-17 and TLR4 in Patients with COPD and Their Correlation with FEV1%pred mMRC Grading and CAT Score. HeBei Med, 2020, 26(10): 1630-1633.
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2020, Vol. 26 
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