Effects of Butylphthalide Soft Capsule Combined with Brain Protein Hydrolysate on NIHSS Score and Keap1-Nrf2/ARE Signaling Pathway in Patients with Acute Cerebral Infarction
ZHANG Lipan, ZHU Yunliang
The Affiliated Hospital of Shandong Jining Medical College, Shandong Jining 272029, China
Abstract：Objective: To investigate the effects of butylphthalide soft capsule combined with brain protein hydrolysate on neurological function (NIHSS) score and Keap1-Nrf2/ARE signaling pathway in patients with acute cerebral infarction (ACI).Methods: From August 2016 to July 2019, 93 patients with ACI in our hospital were selected as the research objects, and they were simply randomized into 3 groups, with 31 cases in each.Besides conventional treatment, control group A was also treated with brain protein hydrolysate, and the control group B was additionally treated with butylphthalide soft capsules, and the observation group was treated with protein hydrolysate combined with butylphthalide soft capsule.The clinical efficacy and vascular pseudohemophilic factor (VWF), adiponectin (APN), interleukin (IL)-8, IL-19, tumor necrosis factor (TNF)-α, superoxide Dismutase (SOD), malondialdehyde (MDA), Keap1-Nrf2/ARE signalling pathway-related protein levels, NIHSS scores, and daily living (Barthel index) of the three groups were compared statistically.Results: The clinical efficacy of the observation group was higher than that of control groups A and B (P＜0.05).After the course of treatment, the NIHSS score of the observation group was lower than those of control groups A and B, and the Barthel index was higher than that of control groups A and B (P<0.05).After the treatment course, the serum VWF and MDA levels in the observation group were lower than those in the control groups, and the APN and SOD levels were higher than those in the control groups (P<0.05).After the course of treatment, the serum levels of IL-19, IL-8 and TNF-α in the observation group were lower than those in the control groups (P<0.05).After the treatment course, the expression level of Keap1 in the observation group was lower than that in the control groups, and the expression levels of NQO1, ARE, and Nrf2 were higher than those in the control groups (P<0.05).Conclusion: Butylphthalide soft capsule combined with brain protein hydrolysate for the treatment of ACI can obviously improve the vascular endothelial function of patients, inhibit oxidative stress response and inflammatory response, regulate Keap1-Nrf2/ARE signaling pathway related proteins, improve neural function and ability of daily living.The effectiveness is significant.
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2020, Vol. 26 
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