食管鳞癌根治术患者组织中CD8<sup>+</sup>/FOXP3<sup>+</sup>比值及PD-L1表达与预后的相关性

doi:10.3969/j.issn.1006-6233.2020.09.09

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摘要 目的: 探讨食管鳞癌(ESCC)根治术患者组织中CD8⁺/FOXP3⁺比值及程序性死亡分子配体1(PD-L1)表达与预后的相关性。方法: 将2014年1月至2019年1月我院行ESCC根治术患者的存档蜡块和癌旁正常组织(距病变部位>5cm处,且证实为无癌浸润)石蜡标本各110例作为研究对象。采用免疫组化法检测ESCC组织中CD8⁺、FOXP3⁺、PD-L1的表达与患者病理参数、预后的关系。结果: CD8⁺/FOXP3⁺在ESCC组织中的阳性表达率低于癌旁组织,PD-L1在ESCC组织中的阳性表达率高于癌旁组织(P<0.05)。单因素和多因素分析显示,TNM T3期分期、合并淋巴结转移、PD-L1阳性表达、CD8⁺/FOXP3⁺阴性表达是影响ESCC患者预后的独立危险因素(P<0.05)。结论: CD8⁺/FOXP3⁺阳性表达、PD-L1阴性表达、TNM分期为T3期、有淋巴结转移是影响ESCC根治术后患者预后的独立危险因素。

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	张成伟
	唱宽
	毛志刚
	舒建

关键词 ：食管鳞癌, 根治术, CD8⁺/FOXP3⁺比值, PD-L1

Abstract：Objective: To explore the correlation between CD8⁺/FOXP3⁺, expression of programmed death ligand 1 (PD-L1) in tissues and prognosis of patients undergoing radical operation of esophageal squamous carcinoma (ESCC).Methods: During the period from January 2014 to January 2019, 110 archived wax specimens and 110 wax specimens of normal tissues adjacent to the cancer (longer than 5 cm away from lesion, confirmed as cancer-free infiltration) from patients who underwent radical operation of ESCC in the hospital were enrolled as study objects.The expression of CD8⁺, FOXP3⁺ and PD-L1 in ESCC tissues was detected by immunohistochemistry, and the relationship between pathological parameters and prognosis was analyzed.Results: The positive expression rate of CD8⁺/FOXP3⁺ in ESCC tissues was lower than that in adjacent tissues, while the positive expression rate of PD-L1 was higher than adjacent tissues (P<0.05).Univariate and multivariate analysis showed that TNM stage T3, lymph node metastasis, positive expression of PD-L1 and negative expression of CD8⁺/FOXP3⁺ were independent risk factors affecting prognosis of ESCC patients (P<0.05).Conclusion: Positive expression of CD8⁺/FOXP3⁺, negative expression of PD-L1, TNM stage T3 and lymph node metastasis are independent risk factors affecting prognosis of patients after radical operation of ESCC.

Key words： Esophageal squamous carcinoma Radical operation CD8⁺/FOXP3⁺ PD-L1

基金资助:辽宁省卫生厅科研基金项目,(编号:2017D05215)

引用本文:

张成伟, 唱宽, 毛志刚, 舒建. 食管鳞癌根治术患者组织中CD8⁺/FOXP3⁺比值及PD-L1表达与预后的相关性[J]. 河北医学, 2020, 26(9): 1441-1445.
ZHANG Chengwei, CHANG Kuan, MAO Zhigang, et al. The Correlation Between CD8⁺/FOXP3⁺ Ratio PD-L1 Expression in Tissues and Prognosis in Patients Undergoing Radical Operation of Esophageal Squamous Carcinoma. HeBei Med, 2020, 26(9): 1441-1445.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2020.09.09 或 http://www.hbyxzzs.cn/CN/Y2020/V26/I9/1441

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