Abstract：Objective: To study the curative effect of norepinephrine combined with milrinone in treating children with septic shock and the effects on serum levels of α-hydroxybutyrate dehydrogenase (HBDH), procalcitonin (PCT), hs-CRP.Methods: 100 children with septic shock admitted to our hospital from May 2017 to May 2019 were selected for the study, and were divided into the observation group (n=51) and the control group (n=49) by the random number table method.The control group was treated with norepinephrine, and the observation group was treated with norepinephrine and milrinone.The clinical effectiveness, serum α - HBDH, PCT, hs CRP, PaCO2, pH, acute physiological and chronic health status scoring system II (APACHE II), sequential organ failure assessment (SOFA), admission time to intensive care unit (ICU) and 28-day mortality were compared between the two groups.Results: After treatment, the total effective rate of the observation group was 96.08%, significantly higher than that of the control group (79.59%) (P<0.05).After treatment, the serum levels of α- HBDH, PCT and hs-CRP in both groups were improved, and the serum levels of α- HBDH, PCT and hs-crp in the observation group were significantly lower than those in the control group (P<0.05).Before treatment, there was no significant difference in blood gas level between the two groups.After treatment, the blood gas indexes of the two groups were improved, and the PaCO2 and pH levels of the observation group were significantly lower than those of the control group (P<0.05).After treatment, APACHE Ⅱ, SOFA score level of the two groups are improved, and in the observation group, APACHE Ⅱ, SOFA scores were significantly lower than control group (P<0.05).The ICU admission time, 28d mortality and total mortality of the observation group were significantly lower than those of the control group, with significant differences (P<0.05).Conclusion: Norepinephrine combined with milinone has a significant effect on the serum levels of α- HBDH, PCT and hs-CRP in children with septic shock.
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2020, Vol. 26 
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