Abstract：Objective: To explore the correlation between plasma Cortisol (Cor), neuron-specific enolase (NSE), insulin resistance (IR) and prognosis of patients with hypertensive cerebral hemorrhage (HCH).Methods: A total of 106 HCH patients were enrolled and divided into survival group (88 cases) and death group (18 cases) according to their prognosis.According to neurological deficit degree, they were divided into mild group (70 cases), moderate group (26 cases) and severe group (10 cases).Fifty middle-aged and elderly health controls in the same period were enrolled as control group.The levels of plasma Cor, NSE, fasting blood glucose (FBG) and fasting insulin were detected within 24h after confirming.IR index was calculated.Results: The levels of Cor and NSE, and IR index in cerebral hemorrhage group were higher than those in control group (P<0.05).Cor level in moderate group and severe group was higher than that in mild group (P<0.05).NSE level in severe group was higher than that in mild group and moderate group (P<0.05).IR index in moderate group and severe group was higher than that in mild group (P<0.05).The levels of Cor and NSE, and IR index were positively correlated with NIHSS score (r=0.325, r=0.530, r=0.336, P<0.05).The levels of Cor and NSE, and IR index in death group were higher than those in survival group (P<0.05).The high-level Cor (β=0.853, OR=2.347, 95%CI = 1.286-4.283), high-level NSE (β=0.469, OR=1.598, 95%CI=1.258-2.030) and increased IR index (β=0.543, OR=1.721, 95%CI=1.112-2.665) were positively correlated with unfavorable prognosis.Conclusion: The levels of plasma Cor and NSE, and IR are closely related to disease severity and prognosis of HCH patients.
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2020, Vol. 26 
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