Abstract：Objective: To investigate the expressions and clinical significance of creatine kinase (CK) and lactate dehydrogenase (LDH) in serum of neonatal bilirubin encephalopathy. Methods: 120 children with hyperbilirubinemia who were hospitalized in Qingdao Municipal Hospital from January 2017 to October 2019 were selected, among them, 67 children with bilirubin encephalopathy were in the case group and 53 children without bilirubin encephalopathy were in the control group. The levels of serum CK and LDH were measured by enzymology rate method; the level of serum total bilirubin (TBIL) was measured by caffeine azo colorimetry; Pearson correlation method was used to analyze the correlations between the levels of serum CK, LDH and level of serum TBIL, BAEP; and the related factors of neonatal bilirubin encephalopathy were analyzed. Results: The peak value of serum total bilirubin, the proportion of acidosis, the level of serum TBIL and BAEP in the case group were significantly higher than those in the control group (P<0.05); the levels of serum CK and LDH in the case group were significantly higher than those in the control group (P<0.05); the results of Pearson analysis showed that the levels of serum CK and LDH were positively correlated with level of serum TBIL and BAEP (P<0.001); and the results of logistic regression analysis showed that the main risk factors of bilirubin encephalopathy were high peak value of total bilirubin, acidosis, serum CK and LDH levels (P<0.05). Conclusion: The levels of CK and LDH in the serum of neonatal bilirubin encephalopathy are increased, which are certainly related to the level of serum TBIL and BAEP. They are risk factors of neonatal bilirubin encephalopathy and may be used as reference indexes to evaluate neonatal bilirubin encephalopathy.
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2020, Vol. 26 
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