Abstract：Objective: To analyze the application of contrast-enhanced ultrasound combined with quantitative analysis in the diagnosis of benign and malignant thyroid nodules. Methods:Retrospective analysis was conducted of clinical data of 72 patients with thyroid nodules who underwent contrast-enhanced ultrasound examination in our hospital from May 2019 to December 2019. The characteristics of contrast-enhanced ultrasound enhancement mode of benign and malignant thyroid nodules were observed. The time-intensity curve was used to analyze blood flow perfusion parameters such as contrast medium transit time, peak intensity, peak time, and area under the curve. Using the postoperative pathological results as a control, the diagnostic value of contrast-enhanced ultrasound combined with quantitative analysis technology was analyzed. Results: Contrast-enhanced ultrasound showed that among 72 patients with thyroid nodules, 43 were benign nodules and 29 were malignant nodules. The pathological types of benign nodules are thyroid adenomas and nodular goiters. Their contrast-enhanced ultrasound features are uniform enhancement or no enhancement inside, peripheral ring enhancement, and clear boundaries. The pathological types of malignant nodules are papillary thyroid carcinoma. Contrast-enhanced ultrasound is characterized by low or uneven enhancement, irregular morphology, and blurred borders. Postoperative pathology confirmed 47 benign nodules and 25 malignant nodules. The sensitivity of contrast-enhanced ultrasound in diagnosing malignant thyroid nodules was 88.00%, the specificity was 85.11%, and the accuracy was 86.21%.Compared with benign thyroid nodules, Peak and AUC in diagnosing malignant thyroid nodules were relatively lower, and had a later TIP (P<0.05). Compared with normal tissues surrounding thyroid malignant nodules, Peak and AUC of thyroid malignant nodules were lower and TIP was later (P<0.05). Compared with normal tissue around benign thyroid nodules, Peak and AUC of benign thyroid nodules were slightly lower, TIP was slightly later, and MTT was slightly slower, but there were no significant differences(P>0.05). Conclusion: Contrast-enhanced ultrasound combined with quantitative analysis technology can be used for the differential diagnosis of benign and malignant thyroid nodules, and the quantitative parameters Peak, AUC and TIP can reflect the vascular perfusion regularity of malignant thyroid nodules.
塔娜, 王霞, 景江新, 景江新. 超声造影联合定量分析技术在甲状腺良恶性结节诊断中的应用分析[J]. 河北医学, 2020, 26(8): 1343-1346.
TA Na, WANG Xia, JING Jiangxin. Contrast-Enhanced Ultrasound Combined with Quantitative Analysis in the Diagnosis of Benign and Malignant Thyroid Nodules. HeBei Med, 2020, 26(8): 1343-1346.
2020, Vol. 26 
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