Abstract：Objective: To analyze the effects of propranolol combined with methimazole on serum parathyroid hormone (PTH), osteocalcin (OCN), alkaline phosphatase (ALP), calcium (Ca) and phosphorus (P) levels in patients with hyperthyroidism. Methods: A total of 200 patients with hyperthyroidism who were admitted to the hospital from December 2017 to December 2018 were selected as subjects. They were divided into the observation group (n=100) and the control group (n=100) with simple random method. The control group was treated with methimazole while the observation group was treated with propranolol combined with methimazole. The clinical curative effect, serum PTH, OCN, ALP, Ca and P levels, the incidence of adverse reactions and recurrence rate were compared between the two groups. Results: After treatment, the levels of serum PTH and Ca in the observation group were significantly higher than those in the control group. The levels of OCN, ALP and P were significantly lower than those in the control group (P<0.05). The total effective rate of the observation group after treatment was significantly higher than that of the control group (88.00% vs 70.00%) (P<0.05). The incidence of adverse reactions in the observation group after treatment was significantly lower than that in the control group (6.67% vs 24.44%) (P<0.05).The recurrence rate of the observation group was 3.00%, which was significantly lower than that of the control group (11.00%) (P<0.05). Conclusion: The clinical curative effect of propranolol combined with methimazole is obvious in the process of hyperthyroidism treatment. The comprehensive treatment can reduce the levels of serum OCN, ALP and P, and increase the levels of PTH and Ca.
徐文, 陈朝聪, 徐文娟. 普萘洛尔与甲巯咪唑联合治疗对甲亢患者血清PTH OCN ALP及血钙 血磷水平的影响[J]. 河北医学, 2020, 26(8): 1304-1306.
XU Wen, CHEN Chaocong, XU Wenjuan. Effects of Propranolol Combined with Methimazole on Serum PTH OCN ALP Ca and P Levels of Patients with Hyperthyroidism. HeBei Med, 2020, 26(8): 1304-1306.
2020, Vol. 26 
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