Abstract：Objective: To explore the predictive value of serum heparanase (HPA), interleukin (IL) -6 on the hemorrhage volume in patients with aneurysmal subarachnoid hemorrhage (aSAH) and its risk factors, so as to provide theoretical basis for clinical diagnosis and treatment. Methods: From June 2015 to June 2019, 219 patients with aSAH were selected as the study subjects. According to glasgow outcome scale (GOS), the patients were divided into poor prognosis group (85 cases) and good prognosis group (134 cases). The serum levels of HPA, IL-6 and hs-CRP were measured by ELISA. Univariate analysis and multivariate logistic regression were used to analyze the risk factors of prognosis in patients with aSAH. The predictive value of serum HPA, IL-6 and hs-CRP on prognosis in patients with aSAH were evaluated by ROC curve. Results: The serum levels of HAL, IL-6 and hs-CRP in patients with poor prognosis group were higher than those of in patients with good prognosis group (P<0.01). The area under ROC curve of HPA, IL-6 and hs-CRP were 0.846 (95% CI:0.791-0.891), 0.818 (95% CI:0.761-0.867) and 0.732 (95% CI:0.668-0.790) respectively in predicting large hemorrhage volume in patients with Asah, and the prediction effect of HAP and IL-6 were better than hs-CRP. The multivariate logistic regression analysis showed that the age over 65 years old (OR=3.365), history of hypertension (OR=1.792), GCS score <12 points (OR=7.699), HPA≥3.91 ng/mL (OR=1.988), IL-6≥47.34 pg/mL (OR=2.195) and hs-CRP≥7.87 mg/L (OR=1.784) were the risk factors of prognosis in patients with aSAH. Conclusion: Serum levels of HPA, IL-6 and hs-CRP are closely related to the prognosis of aSAH patients. They could be used as indicators for predicting the prognosis in patients with aSAH, but the predictive value of HPA and IL-6 are better than those of hs-CRP.
曹兵, 丁奇, 刘春江, 甄诚, 刘熙鹏, 张秀峰, 王鹏飞. 血清HPA和IL-6对动脉瘤性蛛网膜下腔出血患者预后的预测价值[J]. 河北医学, 2020, 26(8): 1269-1272.
CAO Bing, DING Qi, LIU Chunjiang, et al. Predictive Value of Serum HAP IL-6 on the Hemorrhage Volume in Patients with Aneurysmal Subarachnoid Hemorrhage. HeBei Med, 2020, 26(8): 1269-1272.
[1] Chaudhry SR, Hafez A, Rezai JB, et al. Role of damage associated molecular pattern molecules (DAMPs) in aneurysmal subarachnoid hemorrhage (aSAH)[J]. Int Mol Sci, 2018, 19(7): 2035. [2] Liu JF, Song J, Zhao D, et al. Risk factors responsible for the volume of hemorrhage in aneurysmal subarachnoid hemorrhage[J]. Neurol India, 2016, 64(4):686~691. [3] 耿卫峰, 何小娜, 吴勤奋.急性期脑出血患者血清炎症因子、超敏C反应蛋白水平的变化及临床意义[J].新疆医科大学学报, 2018, 41(5):565~568. [4] Jin H, Zhou SB. The functions of heparanase in human diseases[J]. Mini Rev Med Chem, 2017, 17(6):541~548. [5] Feng LY, Qi Q, Wang P, et al. Serum levels of IL-6, IL-8, and IL-10 are indicators of prognosis in pancreatic cancer[J].Int Med Res, 2018, 46(12):5228~5236. [6] 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组.中国蛛网膜下腔出血诊治指南2015[J].中华神经科杂志, 2016, 49(3):182~191. [7] Shetty T, Cogsil T, Dalal A, et al. High-sensitivity C-reactive protein: retrospective study of potential blood biomarker of inflammation in acute mild traumatic brain injury[J].Head Trauma Rehabil, 2019, 34(3):E28~E36. [8] Vlodavsky I, Gross-Cohen M, Weissmann M, et al. Opposing functions of heparanase-1 and heparanase-2 in cancer progression[J]. Trends Biochem Sci, 2018, 43(1):18~31. [9] Breier G. Heparanase and thrombin: common signalling pathways in melanoma cells[J]. Thromb Haemost, 2018, 118(10):1688~1689. [10] Turan N, Edwards MJ, Bates S, et al. IL-6 pathway upregulation in subgroup of severe asthma is associated with neutrophilia and poor lung function[J]. Clin Exp Allergy, 2018, 48(4):475~478. [11] Sun LJ, Li Y, Jia XZ, et al. Neuroprotection by IFN-γ via astrocyte-secreted IL-6 in acute neuroinflammation[J]. Oncotarget, 2017, 8(25):40065~40078.
2020, Vol. 26 
冀公网安备13080202000677号