Abstract：Objective: To study the effects of madopar combined with pramipexole on plasma microRNA -124(miR-124), microRNA -137(miR-137) and non-motor symptoms in patients with Parkinson's disease. Methods: 82 patients with Parkinson's disease who were treated in our hospital from July 2017 to April 2019 were randomly divided into control group and research group, 41 cases in each. The control group was treated with madopar, The research group was treated with madopar and pramipexole. The clinical effects of the two groups were observed and compared. The Parkinson's disease score scale (UPDRS), plasma miR-124 and miR-137 levels, improvement of non-motor symptoms and drug side effects were recorded and compared. Results: 3 months after treatment, the total effective rate of the research group was higher than that of the control group (P<0.05). One month and three months after treatment, the UPDRS scores of the two groups decreased, and the research group was lower than the control group. The UPDRS scores of the two groups were statistically different concerning different treatment methods and time (P<0.05). One month and three months after treatment, the plasma miR-124 in the two groups increased, and the research group was higher than the control group. the plasma miR-137 in the two groups decreased, and the research group was lower than the control group. the plasma miR-124 and miR-137 in the two groups were statistically different in different treatment methods and time (P<0.05). The rates of depression, anxiety and insomnia in the study group were lower than those in the control group (P<0.05). there was no statistical difference in the incidence rates of cognitive impairment, somnolence, constipation and hypotension between the two groups (P>0.05). There was no statistical difference in the total incidence of side effects between the two groups (P>0.05). Conclusion: Madopar combined with pramipexole can improve the curative effect of Parkinson's disease, regulate the expression of miR-124 and miR-137 in plasma, and improve non-motor symptoms.
王静, 张卓, 李雪. 美多芭联合普拉克索对帕金森病患者血浆miR-124 miR-137和非运动症状的影响[J]. 河北医学, 2020, 26(8): 1264-1268.
WANG Jing, ZHANG Zhuo, LI Xue. Effects of Madopar Combined with Pramipexole on Plasma MicroRNA -124, MicroRNA -137 and Non-Motor Symptoms in Patients with Parkinson's Disease. HeBei Med, 2020, 26(8): 1264-1268.
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2020, Vol. 26 
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