雷珠单抗对糖尿病视网膜病变患者手术前后血清VE-cadherin和bFGF的影响

doi:10.3969/j.issn.1006-6233.2020.08.002

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摘要 目的: 探究雷珠单抗对糖尿病视网膜病变患者手术前后血清中血管内皮钙粘蛋白(VE-cadherin)和碱性成纤维细胞生长因子(bFGF)的影响。方法: 选取本院2018年3月至2019年5月收治的糖尿病视网膜病变患者85例作为研究对象, 随机分为两组, 研究组43例, 对照组42例。其中对照组给予玻璃体切除术, 研究组在对照组基础上配合玻璃体腔注射雷珠单抗治疗。观察两组手术情况、术后视力改善情况及血清中血管内皮生长因子(VEGF)、bFGF和VE-cadherin水平变化情况, 并评估术后并发症发生率。结果: 研究组患者手术时间与术中出血量均显著少于对照组(P<0.05), 术后黄斑中心凹视网膜厚度明显小于对照组(P<0.05), 视力改善率明显高于对照组(83.72 % VS 57.14 %, P<0.05);治疗后, 两组患者血清VEGF、bFGF和VE-cadherin水平均较治疗前降低(P<0.05), 且研究组患者血清VEGF、bFGF和VE-cadherin水平均明显低于对照组(P<0.05);此外, 研究组治疗后术后并发症发生率为6.98 %, 明显低于对照组23.81%(P<0.05)。结论: 切除术前玻璃体腔内注射雷珠单抗可优化手术环境, 降低手术风险, 有效改善视力, 减少术后并发症, 临床疗效显著, 值得推广。

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	孙文娟
	纪风涛
	李永蓉

关键词 ：糖尿病视网膜病变, 雷珠单抗, 玻璃体术, 血管内皮钙粘蛋白, 碱性成纤维细胞生长因子

Abstract：Objective: To investigate the effects of razumab on serum vascular endothelial cadherin (VE-cadherin) and basic fibroblast growth factor (bFGF) in patients with diabetic retinopathy during vitrectomy. Methods: 85 patients with diabetic retinopathy admitted to our hospital from March 2018 to May 2019 were randomly divided into two groups, 43 cases in study group and 42 cases in control group. The control group received vitrectomy, while the study group received intravitreal injection of razumab on the basis of the control group. The operation condition, visual acuity improvement and levels of serum vascular endothelial growth factor (VEGF), bFGF and VE-cadherin were observed in the two groups, and the complications were evaluated. Results: The operation time and intraoperative bleeding volume in the study group were significantly less than those in the control group (P<0.05). The macular fovea retinal thickness was significantly smaller than that in the control group (P<0.05). The visual acuity improvement rate was significantly higher than that of the control group (83.72 % VS 57.14 %, P<0.05). After treatment, the levels of serum VEGF, bFGF and VE-cadherin in the two groups were lower than those before treatment (P<0.05), and the levels of serum VEGF, bFGF and VE-cadherin in the study group were significantly lower than those in the control group (P<0.05). In addition, the incidence of postoperative complications in the study group was 6.98%, which was significantly lower than 23.81% in the control group (P<0.05). Conclusion: The intravitreal injection of rapunzumab before operation can optimize the operation environment, reduce the risk of operation, effectively improve vision and reduce postoperative complications. The clinical effect is significant and worthy of promotion.

Key words： Diabetic retinopathy Razumab Vitrectomy VE cadherin BFGF(Basic fibroblast growth factor)

基金资助:安徽省自然科学基金项目, (编号:1808084MH049)

引用本文:

孙文娟, 纪风涛, 李永蓉. 雷珠单抗对糖尿病视网膜病变患者手术前后血清VE-cadherin和bFGF的影响[J]. 河北医学, 2020, 26(8): 1237-1240.
SUN Wenjuan, JI Fengtao, LI Yongrong. Effects of Razumab on Serum VE-Cadherin and bFGF in Diabetic Retinopathy Patients Before and After Operation. HeBei Med, 2020, 26(8): 1237-1240.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2020.08.002 或 http://www.hbyxzzs.cn/CN/Y2020/V26/I8/1237

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