Abstract：Objective: To analyze the effect of argatroban on hemorheology, neurological deficit and activity of daily life in patients with posterior circulation cerebral infarction. Methods: A total of 120 patients with posterior circulation cerebral infarction admitted to our hospital from September 2017 to September 2019 were randomly divided into two groups by simple random grouping method: the control group was treated in conventional manner and the treatment group was administered argatroban + conventional. The hemorheology indexes, National Institutes of Health Stroke Scale (NIHSS) and the modified Barthel Index (MBI) of the two groups were compared before and after treatment. During the treatment, thromboelastography and coagulation function were performed in the treatment group to evaluate the effect of agatraban on the improvement of coagulation function. Results: Three months after treatment, Hct and whole blood relative shear rate index (high shear) in the control group were significantly reduced compared with corresponding data before treatment (P< 0.05), but there was no significant change in plasma viscosity and the shear rate of whole blood viscosity (high shear). The Hct, plasma viscosity, whole blood relative shear rate index (high shear) and shear rate of whole blood viscosity (high shear) were significantly reduced compared with corresponding data before treatment, and each index after treatment was significantly reduced compared with control group (P< 0.05). The NIHSS scores of the two groups decreased significantly after 3 months of treatment, and the decrease range of the treatment group after treatment was more significant compared with control group (P< 0.05); compared with corresponding data before treatment, the MBI scores of the two groups after 3 months of treatment were significantly increased, and the increase range of the treatment group after treatment was more significant compared with control group (P< 0.05). The prothrombin time, prothrombin time and activated partial thromboplastin time (APTT) in the treatment group were significantly prolonged compared with control group at 60 mg / d, while the prothrombin time, prothrombin time and APTT were significantly shorter at 30 mg / d and 2 d after stopping treatment. The comparison of coagulation function indexes at different time points was statistically significant (P< 0.05). After 60 mg / d, the coagulation index and the activity of coagulation factors in the treatment group decreased significantly, while after 30 mg / d and 2 days of withdrawal, the coagulation index and the activity of coagulation factors returned to the normal range (P< 0.05). Conclusion: The application of argatroban can effectively improve the hemorheology and coagulation function of patients with post circulation cerebral infarction, reduce the degree of neurological deficit, improve the ability of daily life activities, and has good safety, so it is worth clinical application.
柳春雨, 武建宏, 杨晓丹. 阿加曲班对后循环脑梗死患者神经功能缺损评分Barthel指数和血液流变学指标的影响[J]. 河北医学, 2020, 26(7): 1079-1083.
LIU Chunyu, WU Jianhong, YANG Xiaodan. The Effect of Argatroban on Neurological Deficit Score Barthel Index and Hemorheology in Patients with Posterior Circulation Cerebral Infarction. HeBei Med, 2020, 26(7): 1079-1083.
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2020, Vol. 26 
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