Abstract:Objective: To study the genotype distribution of partial D variants in Hebei Province. Methods: The five antigens in Rh blood type system of test models were tested serologically,and the RHD genotype was detected by PCR-SSP. Results: 14 partial D samples were found among 107 cases of RhD varients, including 11 D cat.VI type3 cases, 2 D cat.Va type2 cases and 1 D cat.IIIc case. Conclusion:The partial D genotype polymorphisms is detectable in Hebei. Especially D cat.VI type3 is the common genotype.
乔芳, 王宁, 王远花, 钱明明, 郭霞, 赵倩, 田亚娟. 河北地区Rh部分D变异型的基因分布特点[J]. 河北医学, 2020, 26(6): 1045-1047.
QIAO Fang, WANG Ning, Wang Yuanhua, et al. A Research on Genotype Distribution of Partial D Variants in Hebei Province. HeBei Med, 2020, 26(6): 1045-1047.
[1] 臧文正,陈青,张趁利,等.RhD变异型分子生物学特征及其临床意义[J].新乡医学院学报,2019,36(2):172~174. [2] 饶神宗,李归宁,张敏.RhD抗原变异型同种免疫反应研究[J].临床血液学杂志,2017,30(8):591~593. [3] 骆宏,温机智,张润青.RhD变异型个体的表型类型和基因突变机制研究[J].中国实验血液学杂志,2017,25(6):1804~1809. [4] 温机智,贾双双,廖志坚.32名RhD变异型献血者分子遗传背景研究[J].中国输血杂志,2019,32(2):154~157. [5] 蔡健辉,胥利民,张艳梅.RhD变异型病例1例报道[J].检验医学,2019,34(2):187~188. [6] 胡彬,冯智慧,朱于莉.青岛地区RhD阴性及D变异型无偿献血者RHD基因的多态性研究[J].中华医学遗传学杂志,2017,34(6):897~900. [7] He J, Ying Y, Hong X, et al. Molecular basis and zygosity determination of D variants including identification of four novel alleles in chinese individuals[J]. Transfusion, 2015, 55(1): 137~143. [8] 梁倩妮,廖志坚,张润青,等.产生抗D的DVItype3型孕妇免疫血清学和RHD基因型分析[J].中国实验血液学杂志,2017,25(6):1810~1814. [9] 马印图,李莉华,马健华.RhD变异型患者产生类同种抗-D抗体一例分析[J].临床误诊误治,2018,31(3):63~66.