Abstract：Objective: To explore the clinical significance of changes of hemorheology indexes and serum inflammatory factors in patients with delayed union of fracture. Methods: The medical records of 120 fracture patients treated in our hospital from February 2018 to February 2019 were analyzed retrospectively. According to the condition of fracture healing within 4 months after operation, 68 cases in delayed healing group and 52 cases in normal healing group were divided into two groups. The hemorheology indexes, serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) and tumor damage were analyzed by means of repeated measurement of variance analysis The levels of TNF-α, IGF-1, PDGF and ALP were measured. Results: The results of repeated measurement analysis of variance showed that there were statistical significance (P<0.05) in RBC rigidity index, RBC aggregation index, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, sICAM-1, sVCAM-1, TNF-α, IGF-1, PDGF and ALP time factors, time factors and group interaction. After 4, 8 and 12 weeks of fracture, the RBC rigidity index, RBC aggregation index, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, sICAM-1, sVCAM-1, TNF-α levels in the delayed healing group were significantly higher than those in the normal healing group, and the levels of IGF-1, PDGF and ALP were significantly lower than those in the normal healing group (P<0.05). Conclusion: With the prolongation of time, the cell rigidity index, RBC aggregation index, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, sICAM-1, sVCAM-1, TNF-α, IGF-1, PDGF and ALP levels in the two groups increased first and then decreased, among which cell rigidity index, RBC aggregation index, plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, sICAM-1, s VCAM-1 and TNF-α fluctuated significantly with time in delayed union fractures, while IGF-1, PDGF and ALP levels fluctuated significantly in normal fractures.
徐向勇, 余永斌. 血流变学指标血清炎症因子水平变化在骨折延迟愈合患者中的临床研究[J]. 河北医学, 2020, 26(5): 810-815.
XU Xiangyong, YU Yongbin. Clinical Study on the Changes of Hemorheology Indexes and Serum Inflammatory Factors in Patients with Delayed Union of Fracture. HeBei Med, 2020, 26(5): 810-815.
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2020, Vol. 26 
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