Abstract：Objective: To investigate the clinical value of endoscopic submucosal dissection (ESD) guided by mini-probe endoscopic ultrasonography in the diagnosis and treatment of gastric mucosal protrusion lesions. Methods: The clinical data of 194 patients with gastric mucosal protrusion confirmed by operation and pathology were analyzed retrospectively. The diagnostic value of micro probe endoscopic ultrasonography and general gastroscopy in gastric mucosal protuberant lesions were analyzed. 194 patients were divided into ESD group (n=102) and EMR group (n=92) according to the operation mode. The operation related indexes (whole resection rate, operation time, intraoperative bleeding volume) and complications were recorded. The difference of stress response (noradrenaline (NE), cortisol (COR)) between the two groups before and 1 day after operation was compared. Results: Of the 194 patients with gastric mucosal protrusion lesions, there were 78 cases of polyps, 51 cases of interstitialoma, 42 cases of liomyoma and 23 cases of lipomyoma. The diagnostic accuracy rate of mini-probe endoscopic ultrasonography was significantly higher than that of common gastroscopy in the diagnosis of gastric mucosal protrusion lesions (P<0.05). The block resection rate in ESD group was significantly higher than that in EMR group (P<0.05), and the surgery time and intraoperative blood loss were lower than those in EMR group (P<0.05). There were no significant differences in the perioperative complications between the two groups (P>0.05). At 1d after surgery, the stress response indexes (serum NE, Cor) were higher than those before surgery (P<0.05), and the indexes in EMR group were higher than those in ESD group (P<0.05). Conclusion: ESD by mini-probe endoscopic ultrasonography has significant effects in the diagnosis and treatment of gastric mucosal protrusion lesions, and can reduce the surgical stress response, and it is of positive significance in promoting postoperative recovery.
2020, Vol. 26 
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