Abstract：Objective: To investigate the clinical effects of murine nerve growth factor (M-NGF) combined with sodium creatine phosphate in the treatment of neonatal hypoxic ischemic encephalopathy (HIE). Methods: From June 2017 to December 2018, 62 neonates with HIE were simple random number table method divided into two groups (31 cases each).The children in the control group were treated with routine treatment, and the study group was treated with M-NGF combined with creatine phosphate on the basis of the control group for 10 days. Neonatal behavioral nerve score (NBNA), myocardial markers (cTnI, CK-MB, CK), clinical efficacy, and safety were compared between the two groups. Results: Repeated measurement analysis of variance showed that there were significant differences in NBNA score, myocardial between the two groups, and the interaction between the two groups (P<0.05).The results of pairwise comparison within the group showed that the NBNA scores at different time points in the two groups showed a significant upward trend (P<0.05), and cTnI, CK-MB and CK all showed a significant downward trend (P<0.05). Coupled comparisons between groups showed, before treatment, there was no significant difference in NBNA score, myocardial between the two groups (P>0.05).On the 5th and 10th day of treatment, the NBNA score in the study group were higher than those in the control group, and the cTnI,CK-MB,CK levels were lower than those in the control group (P<0.05).The total effective rate of treatment in the study group (96.77%) was higher than that in the control group (70.97%), the difference was statistically significant (χ2=7.631, P<0.05). There were no serious adverse reactions during treatment in both groups. Conclusion: M-NGF combined with creatine phosphate in the treatment of neonatal HIE can significantly improve myocardial function, reduce myocardial injury, promote the recovery of nerve function, improve the clinical efficacy, and has high safety.
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2020, Vol. 26 
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