Clinical Significance and Changes of Serum IL-17 IL-6 and TIMP-2 Levels in Elderly Patients with Inguinal Hernia Before and After Tension-Free Hernioplasty
SHI Xuesong, CAO Hongyong, XIAO Hua
Nanjing Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 210006, China
Abstract:Objective: To observe the changes in levels of serum interleukin-17 (IL-17), interleukin-6 (IL-6) and tissue inhibitor of metalloproteinase (TIMP-2) of elderly patients with inguinal hernia (IH) before and after tension-free hernioplasty (TFH), and to analyze their clinical significance. Methods: 96 elderly IH patients in the hospital who had undergone TFH were enrolled as observation group, and 47 healthy controls in the same period were enrolled as control group. The levels of serum IL-17, IL-6 and TIMP-2 before and after surgery in the observation group were compared with those in the control group. According to different postoperative complications and recurrence, the patients were divided into good prognosis group and poor prognosis group. The levels of serum IL-17, IL-6 and TIMP-2 were compared between the two groups and control group and correlation analysis was conducted. Results: The levels of serum IL-17 and IL-6 after surgery were higher than those before surgery, which were higher than those in control group (P<0.05). Arranging levels of serum IL-17 and IL-6 from low to high, the corresponding order was control group, good prognosis group and poor prognosis group (P<0.05). TIMP-2 level after surgery was lower than that before surgery, which was lower than that in control group (P<0.05). TIMP-2 level was the highest in control group, followed by good prognosis group and poor prognosis group (P<0.05). Serum IL-17 and IL-6 were negatively correlated with prognosis of elderly IH patients undergoing TFH (P<0.05), while serum TIMP-2 was positively correlated with prognosis (P<0.05). Conclusion: Compared with those before surgery, at 24h after surgery, levels of serum IL-17 and IL-6 are significantly increased in elderly IH patients who have undergone TFH, while serum TIMP-2 level is significantly decreased. Their changes are closely related to prognosis, which can provide effective guidance for clinical treatment and prognosis assessment.
施雪松, 曹红勇, 肖华. 老年腹股沟疝无张力修补术前后血清IL-17 IL-6及TIMP-2水平变化及临床意义[J]. 河北医学, 2020, 26(5): 709-713.
SHI Xuesong, CAO Hongyong, XIAO Hua. Clinical Significance and Changes of Serum IL-17 IL-6 and TIMP-2 Levels in Elderly Patients with Inguinal Hernia Before and After Tension-Free Hernioplasty. HeBei Med, 2020, 26(5): 709-713.
[1] Li J,Ji Z,Li Y.Comparison of laparoscopic versus open procedure in the treatment of recurrent inguinal hernia:a meta-analysis of the results.[J].Am Surg,2014,207(4):602~612. [2] Burcharth J.The epidemiology and risk factors for recurrence after inguinal hernia surgery.[J].Dan Med,2014,61(5):4846. [3] De G B,Timmermans L,van Kempen B J,et al.Risk factors for inguinal hernia in middle-aged and elderly men:results from the Rotterdam Study[J].Surgery,2015,157(3):540~546. [4] Mac K L, John C. K, Scott S, et al. The effect of tobacco use on outcomes of laparoscopic and open inguinal hernia repairs: a review of the NSQIP dataset[J]. Surg Endosc, 2017, 31(2): 917~921. [5] Shah N S,Fullwood C,Siriwardena A K,et al.Mesh fixation at laparoscopic inguinal hernia repair: a meta-analysis comparing tissue glue and tack fixation[J].World Surg,2014,38(10):2558~2570. [6] Shillcutt S D,Kingsnorth A N.Commentary on:characterizing the global burden of surgical disease:a method to estimate inguinal hernia epidemiology in ghana[J].World Surg,2014,38(4):997~998. [7] Reddy K M,Humphreys W,Chew A,et al.Inguinal hernia repair with the Kugel patch[J].Anz Surg,2015,75(1-2):43~47. [8] 周凌阳,陈伦宽,陈侃松,等.三种不同腹股沟疝手术修补方案的临床有效性及安全性对照探究[J].中国普通外科杂志,2015,24(4):619~622. [9] 李奎,孙亮,舒若,等.腹腔镜下腹膜前修补术治疗双侧腹股沟疝17例[J].中国微创外科杂志,2015,15(6):533~535.