Abstract：Objective: To investigate the correlation between plasma endothelin-1 (ET-1) level and the degree of lower extremity vascular disease in elderly patients with type 2 diabetes. Methods: A total of 136 elderly patients with diabetes mellitus and lower extremity vascular disease treated in our hospital from January 2015 to January 2019 were randomly selected. Based on the results of ankle brachial index (ABI) measurement in elderly patients, they were divided into a 84 patients mild lower extremity arteriosclerosis group (0.7≤ABI <0.9), a 36 patients moderate lower extremity arteriosclerosis group (0.5≤ABI <0.7), and a 16 patients severe lower extremity arteriosclerosis group (ABI <0.5),Glucose oxidase method was used to measure fasting blood glucose (FBG), chromatographic method was used to measure glycated hemoglobin (HbA1c), and automatic biochemical analyzer was used to measure the cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and triacylglycerol (TG), etc. The enzyme-linked adsorption method was used to measure the plasma ET-1 levels in patients among different lower extremity arteriosclerosis groups, and we analyzed the correlation between the degree of aortic lesions in different limbs and the level of plasma ET-1 . Results: There were significant differences in age, BMI, TC, TG, LDL, HDL, course of disease, blood glucose under fasting, and ET-1 level between groups with different degrees of pathological changes of lower extremity arteries in type 2 diabetes (P <0.05). Logistic regression analysis showed that, fasting blood glucose, duration of diabetes, and ET-1 are independent risk factors that affect the degree of arterial disease in the lower limbs. Spearman rank correlation analysis showed that the degree of diabetic lower extremity vascular lesions was positively correlated with ET-1 (r = 0.336, P = 0.000). Conclusion: The independent risk factors for the degree of lower extremity vascular disease in type 2 diabetes are fasting blood glucose, duration of diabetes, which are positively correlated with ET-1 level.
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2020, Vol. 26 
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