Abstract：Objective: To explore the effects of fasudil on cardiac function and B-type diuretic natriuretic peptide (BNP), high-sensitivity c-reactive protein (hs-CRP), plasma endothelin-1 (ET-1) and plasma natriuretic peptide (ANP) in patients with heart failure. Methods: 78 patients with heart failure diagnosed and treated in our hospital from September 2018 to September 2019 were selected as the study objects. They were randomly divided into study group and control group, respectively, with 39 patients. In the study group, patients were treated with fasudil, and patients in the control group were treated with conventional treatment. The differences of cardiac function, BNP, hs-crp, et-1 and ANP between the two groups were compared. Results: The NYHA of the two groups were classified as grade III and grade IV before treatment, and grade I and grade II after treatment. There was no significant difference between the two groups (P>0.05). The time of repeated measurement showed the difference before and after treatment was statistically significant (P<0.05). Repeated measurement variance showed that the time point, inter group, and inter group interaction effects of LVEF, LVEDd, LVESd, BNP, hs-CRP, ET-1, ANP in the two groups were statistically significant (P<0.05), and 1, 2, and 3 months after treatment, the level of LVEF in the study patients was higher than that in the control group (P<0.05), and the levels of LVEDd, LVESd, BNP, hs-CRP, ET-1, and ANP were lower than those in the control group Significance (P<0.05). Conclusion: The application of fasudil in patients with heart failure can effectively improve the cardiac function of patients, and has positive significance in reducing the levels of BNP, hs-crp, et-1 and ANP in patients, which is worthy of clinical promotion.
陈红梅, 李绍生. 法舒地尔对心衰患者心功能及BNP hs-CRP ET-1 ANP的影响[J]. 河北医学, 2020, 26(4): 576-580.
CHEN Hongmei, LI Shaosheng. Effects of Fasudil on Cardiac Function and BNP hs-CRP ET-1 and ANP in Patients with Heart Failure. HeBei Med, 2020, 26(4): 576-580.
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2020, Vol. 26 
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