Abstract：Objective: To study the relationship between control blood lipid level, erythrocyte distribution width (RDW) and endothelin-1 (ET-1) and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 108 patients with coronary heart disease underwent PCI in our hospital from January 2016 to January 2019 were enrolled. Coronary angiography was performed 3 to 12 months after surgery. Patients were divided into ISR group according to angiographic results. There were 17 cases and 91 cases of non-ISR group. Blood lipid levels [total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)] were measured before PCI and before coronary angiography. The levels of RDW and ET-1 were measured before coronary angiography, and the relationship between serum lipid levels, RDW and ET-1 and ISR in patients with CHD after PCI was analyzed. Results: The levels of TC, TG, and LDL-C before coronary angiography in the ISR group were significantly higher than those in the non-ISR group (P<0.05). The levels of RDW and ET-1 in the ISR group were significantly higher than those in the non-ISR group. The differences were statistically significant (P<0.05). Logistic multivariate regression analysis results showed that TC did not decrease and LDL-C did not meet the target (controlled at 1.8 mmoL/L before coronary angiography) were risk factors for postoperative ISR in patients with coronary heart disease (P<0.05). TG did not decrease and HDL -C is not a risk factor for postoperative ISR in patients with coronary heart disease (P﹥0.05); RDW and ET-1 are risk factors for postoperative ISR in patients with coronary heart disease (P<0.05). Conclusion: TC, LDL-C, RDW and ET-1 are the high risk factors of ISR in patients with CHD after PCI. The detection of TC, LDL-C, RDW and ET-1 is helpful to evaluate the risk of ISR.
刘恒友, 鲁锦国, 刘小河, 王春明, 胡晓军. 血脂控制水平 RDW及ET-1与冠心病患者PCI术后支架内再狭窄的关系研究[J]. 河北医学, 2020, 26(4): 545-549.
LIU Hengyou, LU Jinguo, LIU Xiaohe, et al. Relationship between Serum Lipid Levels RDW and ET-1 andIn-stent Restenosis after PCI in Patients with CHD. HeBei Med, 2020, 26(4): 545-549.
[1] Mcdonald R A, Halliday C A, Miller A M, et al. Reducing In-Stent Restenosis[J]. Journal of the American College of Cardiology, 2015, 65(21):2314~2327. [2] 谷臣锋,刘剑雄,郑庆昆,等.中老年冠心病患者冠状动脉药物洗脱支架置入术后支架内再狭窄的相关因素分析[J].四川医学,2017,38(7):797~801. [3] 赵存瑞,白明,张博,等.血脂控制水平与冠状动脉支架置入术后支架内再狭窄的相关性研究[J].中国循环杂志,2015,30(7):644~646. [4] 王聪霞,贾珊.冠状动脉支架内再狭窄发生机制的研究进展[J].西安交通大学学报(医学版),2018,39(3):303~309. [5] 葛均波,徐永健.内科学[M].第8版.人民卫生出版社,2013. [6] Barbieri L, Verdoia M, Schaffer A, et al. Risk and benefits of triple therapy in patients undergoing coronary stent Implantation requiring oral anticoagulation: a meta-analysis of 16 studies[J]. Cardiovascular Drugs & Therapy, 2016, 30(6):611~622. [7] Piao Z H, Jin L, Kim J H, et al. Benefits of statin therapy in patients with acute myocardial infarction with serum low-density lipoprotein cholesterol ≤ 50 mg/dl.[J]. American Journal of Cardiology, 2017, 120(2):174~180. [8] Wang Z, Song H Y, An M M, et al. Association of serum SPARC level with severity of coronary artery lesion in type 2 diabetic patients with coronary heart disease[J]. Clinical Focus, 2015, 8(10):19290~19296. [9] 张冬花,李志忠,张京梅,等.红细胞分布宽度与冠心病患者经皮冠状动脉介入治疗术后支架内再狭窄的相关性研究[J].中国综合临床,2017,33(12):1084~1088. [10] Martinez-Godinez M A, Cruz-Dominguez M P, Jara L J, et al. Expression of NLRP3 inflammasome, cytokines and vascular mediators in the skin of systemic sclerosis patients.[J]. Israel Medical Association Journal Imaj, 2015, 17(1):5~10.
2020, Vol. 26 
冀公网安备13080202000677号