Effects of Different Proportions of Blood Component Transfusion on Coagulation Parameters, Hemostasis Rate and Short-term Prognosis in Patients with Severe Trauma
YU Guifen, WENG Wenhao, LI Hanhua, et al
Yangpu Hospital Affiliated to Tongji University, Shanghai 200090, China
Abstract：Objective: To study the effects of different proportions of blood component transfusion on coagulation function, hemostasis rate and short-term prognosis in patients with severe trauma. Methods: The general data of patients with severe traumaadmitted to our hospital from June 2016 to June 2018 were retrospectively analyzed. According to the infusion proportion of plasma (FP) and red blood cell (RBC), they were divided into group A (FP: RBC≤1:2, n=21), group B (1:2 < FP: RBC < 1:1,n=26) and group C (FP: RBC ≥1:1, n=20).The coagulation function, blood routine, hemostasis rate, survival rate and blood product usage were observed in the three groups before and after blood transfusion treatment. Results: The prothrombin time (PT) and activated partial thromboplastin time (APTT) in the three groups were significantly prolonged compared with those before blood transfusion, and the international normalized ratio (INR) level was increased significantly while the fibrinogen (FIB) level was significantly decreased (P<0.05), and there were significant differences in the PT, INR, APTT and FIB among the three groups after blood transfusion (P<0.05). The level of hemoglobin (Hb) in group C after blood transfusion was significantly lower than that before blood transfusion (P<0.05), and there was no significant difference in Hb level between group A and group B before and after blood transfusion (P>0.05), and the platelet count (PLT) level in the three groups after blood transfusion was significantly lower than that before blood transfusion (P<0.05), and there was a significant difference in the PLT levels among the three groups after blood transfusion (P<0.05). There was no significant difference in the 28d survival rate among the three groups (P>0.05). There were significant differences among the three groups in the FP and cryoprecipitate usage (P<0.05), and there was no significant difference in the RBC usage (P>0.05). Conclusion: Blood component transfusion with proportion of 1:2<FP:RBC<1:1 can effectively correct coagulation disorders and blood routine level and improve the prognosis of patients with severe trauma, thus it is worthy of clinical promotion.
于桂芬, 翁文浩, 李汉华, 周雄文. 不同成分输血比例对严重创伤患者凝血指标止血率及近期预后的影响[J]. 河北医学, 2020, 26(3): 518-521.
YU Guifen, WENG Wenhao, LI Hanhua, et al. Effects of Different Proportions of Blood Component Transfusion on Coagulation Parameters, Hemostasis Rate and Short-term Prognosis in Patients with Severe Trauma. HeBei Med, 2020, 26(3): 518-521.
2020, Vol. 26 
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