摘要目的:探讨头孢噻肟钠对围手术期急诊创伤患者感染情况的影响。方法:选取时间2016年1月到2018年12月之间,共包括了120例急诊收治的创伤患者,根据简单随机分组法随机分为两组:对照组60例,行临床常规疗法治疗;实验组60例,在与对照组相同的临床常规治疗基础上予头孢噻肟钠抗感染治疗,检测两组患者体温、白细胞及CRP等指标的变化,评价两种治疗方法的临床疗效,感染率,和伤口愈合率,其数据结果应用统计学软件SPSS19.0加以处理。结果:研究表明,两组患者的白细胞以及体温和CRP水平在术前没有差异(P>0.05)。术后第3天,两组患者体温、WBC、CRP水平均较术前降低,但实验组明显低于对照组(P<0.05)。与对照组相比,实验组的治疗有效率明显更佳(95.00% VS 76.67%)(P<0.05)。治疗后,实验组感染率为3.33%, 明显低于对照组的16.67%,(χ2=5.926,P<0.05)。治疗后,实验组甲级愈合率为51.67%,乙级愈合率为43.33%,丙级愈合率为5.00%;对照组甲级愈合率为31.67%,乙级愈合率为38.33%,丙级愈合率为30.00%;两组比较(U=2.395,P=0.031)。结论:在对于围手术期急诊创伤患者感染情况的治疗中,头孢噻肟钠效果显著,且安全性较高。
Abstract：Objective: To investigate the effect of cefotaxime sodium on the infection of patients with trauma in perioperative period. Methods: A total of 120 trauma patients admitted to the emergency department were enrolled between January 2016 and December 2018. They were simple random grouping into two groups according to the random number table: 60 patients in the control group underwent routine clinical therapy. 60 patients in the group were treated with cefotaxime sodium anti-infective treatment based on the same clinical routine treatment as the control group. The changes of body temperature, white blood cells and CRP were measured in the two groups. The clinical efficacy and infection rate of the two treatment methods were evaluated. And wound healing rate, the data results were processed using statistical software SPSS19.0. Results: The study showed that there were no differences in white blood cell and body temperature and CRP levels between the two groups (P>0.05). On the 3rd postoperative day, the body temperature, WBC and CRP levels of the two groups were lower than those before the operation, but the experimental group was significantly lower than the control group (P<0.05). Compared with the control group, the treatment efficiency of the experimental group was significantly better (95.00% vs 76.67%) (P<0.05). After treatment, the infection rate of the experimental group was 3.33%, which was significantly lower than 16.67% of the control group (χ2=5.926, P<0.05). After treatment, the grade A healing rate was 51.67%, the grade B healing rate was 43.33%, and the grade C healing rate was 5.00%. The grade A healing rate was 31.67%, and the grade B healing rate was 38.33%. The rate was 30.00%; the two groups were compared (U=2.395, P=0.031). Conclusion: In the treatment of infection in perioperative emergency trauma patients, cefotaxime sodium has significant effect and high safety.
谭俊, 张鑫, 赵雪丽. 头孢噻肟钠围手术期应用对急诊创伤患者感染情况影响研究[J]. 河北医学, 2020, 26(3): 502-505.
TAN Jun, et al. Study on the Effect of Perioperative Application of Cefotaxime Sodium on Infection in Emergency Trauma Patients. HeBei Med, 2020, 26(3): 502-505.
2020, Vol. 26 
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