Abstract：Objective: To detect the serum procalcitonin (PCT) and C-reactive protein (CRP) /serum albumin (ALB) ratio in patients with upper urinary tract calculi before and after operation, and to analyze their relationships with perioperative infection. Methods: 180 patients with upper urinary tract calculi who underwent surgery in the Department of Urology of Zhongxiang People's Hospital from April 2017 to May 2019 were selected as the study subjects. According to whether infection occurred at admission, the patients were divided into infection group (n=100) and non-infection group (n=80). The infection group was further divided into significant infection group (n=60) and hidden infection group (n=40). Postoperative infection was divided into infection group (n=42) and non-infection group (n=138). Serum PCT, CRP and Alb levels were measured by automatic biochemical analyzer, and CRP/Alb ratio was calculated. Acute physiology and chronic health score system II (APACHE II) was calculated according to the related indicators and clinical characteristics of patients, White blood cell count (WBC) and red blood cell count (RBC) were measured, and the temperature (T), heart rate (HR) and respiratory rate (RR) were recorded. Results: The numbers of WBC, RBC and APACHE score in the patients with hospital infection were significantly higher than those in the patients without hospital infection (P < 0.05). One day after admission, the levels of serum PCT, CRP, CRP/Alb in the non-infected group were lower than those in the infected and occult infection group (P < 0.05), while the level of Alb was higher (P < 0.05) ; the levels of serum PCT, CRP and CRP/Alb in the occult infection group were lower than those in the infected group (P < 0.05). One day after operation, the levels of PCT, CRP and CRP/Alb in the infected group were significantly higher than those in the non-infected group (P < 0.05), while the level of ALB was lower (P < 0.05). One day after admission, the serum CRP level and CRP/Alb ratio of patients were detected separately, but the sensitivity was not high. The AUC of combined detection for predicting preoperative infection was 0.909, the corresponding sensitivity was 90.50%, and the specificity was 81.70%; One day after operation, the serum PCT level and CRP/Alb ratio were detected separately, which had a certain value in predicting preoperative infection. The combined detection of them predicted preoperative infection with AUC of 0.977, corresponding sensitivity of 92.90% and specificity of 98.60%. Conclusions: The serum PCT and CRP/Alb ratio are increased in patients with infection before and after operation, which may be used as biomarkers for perioperative infection of upper urinary tract stones.
董尚波, 黄江波. 血清PIC和CRP/ACB比值用于预测上尿路结石围手术期感染的应用价值[J]. 河北医学, 2020, 26(3): 407-410.
DONG Shangbo, et al. The Value of Serum PCT and CRP / ALB Ratio in the Prediction of Perioperative Infection of Upper Urinary Tract Calculi. HeBei Med, 2020, 26(3): 407-410.
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2020, Vol. 26 
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