Clinical Effect of Compound Cerebral Peptide Glycoside Injection on Acute Cerebral Infarction and the Effect on LP-PLA2 hs-CRP and NSE Levels in Patients
LI Xingming, LIU Juanjuan, CHEN Junbin, et al
Yuebei People's Hospital Affiliated to Shantou University Medical College, Guangdong Shaoguan 512026, China
Abstract：Objective: To investigate the clinical effect of compound cerebral peptide glycoside injection on acute cerebral infarction and its effect on lipoprotein related phospholipase (LP-PL) A2, hypersensitive C reactive protein (hs-CRP) and neuron-specific enolase (NSE) levels. Methods: 160 patients with acute cerebral infarction hospitalized in our hospital from January 2017 to June 2018 were randomly divided into control group and treatment group, 80 cases each. All the patients were treated according to "2018 Chinese guidelines for the treatment of acute ischemic stroke". Moreover, patients in the treatment group were given compound cerebral peptide glycoside injection for two weeks. All the patients were followed for 3 months. The NIHSS and ADL scores were evaluated before and after treatment and 3 months follow-up between two groups. Furthermore, the changes of Lp-PLA2, hs-CRP and NSE levels before and after treatment were detected in the two groups, and the occurrence of adverse reactions before and after treatment were compared in the two groups. Results: The NIHSS score and ADL of patients were significantly decreased in the two groups, and the levels of Lp-PLA2, hs-CRP and NSE were significantly decreased in the two groups when after treatment compared with before treatment, with statistically significant differences (P<0.05) ; After treatment, NIHSS score in the treatment group was significantly decreased and ADL was significantly increased compared with the control group. The levels of Lp-PLA2, hs-CRP and NSE in the treatment group were obviously lower than those in the control group, with statistically significant differences (P<0.05) ; There was no significant difference in the occurrence of adverse reactions between the two groups (P>0.05). Conclusion: The application of compound cerebral peptide glycoside injection can effectively improve the condition of neurological dysfunction and the quality of life of patients, significantly reduce the levels of Lp-PLA2, hs-CRP and NSE in patients with acute cerebral infarction, and do not increase the occurrence of adverse reactions. It is worthy of further promotion and treatment in clinic.
李兴明, 刘娟娟, 陈俊斌, 刘建祥, 焦臣泽. 复方脑肽节苷脂注射液对急性脑梗死的临床疗效及对患者Lp-PLA2 hs-CRP NSE水平的影响[J]. 河北医学, 2020, 26(3): 393-397.
LI Xingming, LIU Juanjuan, CHEN Junbin, et al. Clinical Effect of Compound Cerebral Peptide Glycoside Injection on Acute Cerebral Infarction and the Effect on LP-PLA2 hs-CRP and NSE Levels in Patients. HeBei Med, 2020, 26(3): 393-397.
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2020, Vol. 26 
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