Abstract：Objective: To study the clinical efficacy of levothyroxine tablets and growth hormone in the treatment of idiopathic short stature in children, and the effects on serum IGF-1 and IGFBP-3 levels. Methods: A total of 110 children with idiopathic short stature admitted to our hospital from June 2014 to July 2018 were enrolled in the study. According to the parity of admission order, they were divided into observation group (odd array) and control group (even array). On the basis of conventional treatment regimen, control group was given recombinant human growth hormone therapy, and observation group was given levothyroxine tablets combined with recombinant human growth hormone, and they were treated for 12 months. The growth effects, thyroid function, levels of serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) and incidence rate of adverse reactions were compared between the two groups. Results: The height, weight, bone age and growth rate in the two groups on the 6th and 12th month of treatment were significantly higher than those before treatment (P<0.05), and the growth rate on the 3rd and 12th month of treatment and weight on the 12th month of treatment in observation group were significantly higher than those in control group (P<0.05). The level of thyroid stimulating hormone (TSH) on the 3rd, 6th and 12th month of treatment were significantly decreased in the two groups (P<0.05) while the levels of serum free triiodothyronine (FT3) and serum free thyroxine (FT4) were significantly increased (P<0.05), and the levels in observation group after treatment were significantly different compared with those in control group (P<0.05). The levels of serum IGF-1 and IGFBP-3 on the 3rd, 6th and 12th month of treatment in the two groups were significantly higher than those before treatment (P<0.05), and the level of IGF-1 in observation group was significantly different from that in control group at the same time (P<0.05). During treatment, the incidence rates of adverse reactions in the two groups were 10.91% and 9.09% respectively (P>0.05). Conclusion: Compared with growth hormone alone, levothyroxine tablets combined with growth hormone for idiopathic short stature in children has achieved better clinical results, and to some extent, it improves the growth effects, promotes thyroid function, and increases levels of serum IGF-1 and IGFBP-3.
马勇, 王继锋, 张微. 左甲状腺素片及生长激素治疗特发性矮小儿童疗效及对血清IGF-1和IGFBP-3水平影响[J]. 河北医学, 2020, 26(3): 374-378.
MA Yong, WANG Jifeng, ZHANG Wei. Effect of Levothyroxine Tablet and Growth Hormone for Idiopathic Short Children and the Influence on Serum IGF-1 and IGFBP-3 Levels. HeBei Med, 2020, 26(3): 374-378.
2020, Vol. 26 
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