Abstract：Objective: To explore the relationship between cytomegalovirus infection and serum TNF-alpha, IL-1 and IL-6 in patients with spontaneous abortion. Methods: The clinical data of 110 cases of spontaneous abortion pregnant women (observation group) and 70 cases of normal pregnant women (control group) were collected from January 2017 to January 2019. The observation group was divided into two subgroups according to the detection results of HCMV-IgM, HCMV-DNA and HCMV-RNA in peripheral blood, and either of them was positive. For HCMV active infection, 26 cases were active infection and 84 cases were inactive infection. The positive rates of HCMV-IgM, HCMV-DNA and HCMV-RNA, the levels of inflammatory cytokines (TNF-a, IL-1, IL-6) and the levels of inflammatory cytokines in active infection group and inactive infection group were compared between the observation group and the control group. The relationship between HCMV active infection and TNF-a, IL-1, IL-6 was analyzed. Results: The positive rates of HCMV-IgM, HCMV-DNA and HCMV-RNA in the observation group were 37.37%, 16.36% and 2364% respectively, which were significantly higher than those in the control group (7.14%, 4.29% and 5.71%), the differences were statistically significant (P<0.05). The serum levels of TNF-alpha, IL-1 and IL-6 in active infection group were higher than those in inactive infection group, the differences were statistically significant (P<0.05), it is suggested that serum TNF - α, IL-1 and IL-6 levels are related to active infection, and the higher the level, the higher the risk of active infection. Conclusion: HCMV infection is one of the important causes of spontaneous abortion, and HCMV infection is related to the levels of TNF - α, IL-1 and IL-6. The higher the level, the higher the risk of active infection, may play an important role in the occurrence of abortion.
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2020, Vol. 26 
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