Abstract：Objective: To study the effects of MRI scan combined with serum GP73 and AFP levels on the diagnostic efficacy of primary hepatic carcinoma (PHC). Methods: 92 patients with suspected PHC from June 2018 to June 2019 in our hospital were selected for the study. According to the results of pathological examination, the patients were divided into PHC group (47 cases) and benign group (45 cases). 50 healthy examiners in our hospital at the same period were selected as control group, and the MRI scan was performed, and the expression levels of serum alpha-fetoprotein (AFP) and Golgi glycoprotein 73 (GP73) were measured and compared. Kappa consistency test was used to analyze the value of each method for the diagnosis of PHC alone or in combination. Results: MRI showed 48 patients with PHC, including 26 cases of nodular type, 17 cases of massive type and 5 cases of diffuse type. T1WI mainly showed even low or slightly low signal, and T2WI mainly showed uneven high signal, and DWI showed obviously enhanced tumor tissues, and the signal intensity was higher than that of surrounding normal tissues, and some cases showed high signal necrosis and low signal hemorrhage. The ADC value in PHC group was significantly lower than that in benign group and control group (P<0.05), and the levels of serum AFP and GP73 were significantly higher than those in benign group and control group (P<0.05), and the ADC value in benign group was significantly lower than that in control group (P<0.05), and the levels of serum AFP and GP73 were significantly higher than those in control group (P<0.05). Taking pathological results as the gold standard, and consistency Kappa test showed that levels of serum AFP and GP73 had lower diagnostic efficacy for PHC (Kappa value <0.5), and combined with MRI examination could effectively improve the diagnostic efficacy (Kappa value 0.5~0.7), and MRI had good diagnostic value for PHC (Kappa value>0.7), and the combined diagnostic accuracy of the three could be further improved (Kappa value > 0.7). Conclusion: MRI scan combined with serum GP73 and AFP levels can effectively improve the diagnostic accuracy of PHC, and it is of great significance for early treatment of PHC and improvement of prognosis.
[1] Chen W,Zheng R,Baade,PD,et al.Cancer statistics in China,2015[J].Ca Cancer Clin,2016,66(2):115~132. [2] Wei G,Kim H,Mitchell H,et al.Human monoclonal antibody targeting the heparan sulfate chains of glypican-3 inhibits HGF-mediated migration and motility of hepatocellular carcinoma cells[J].PLoS ONE,2015,10(9):e0137664. [3] Zhang D,Xu A.Application of dual-source CT perfusion imaging and MRI for the diagnosis of primary liver cancer:[J].Oncol Lett,2017,14(5):5753~5758. [4] 滕建军.原发性肝癌的发病危险因素分析[J].中华肿瘤防治杂志,2016,23(S1):162~163. [5] Lu S,Wang S,Gao Q,et al.Quantitative evaluation of diffusion and dynamic contrast-enhanced magnetic resonance imaging for differentiation between primary central nervous system lymphoma and glioblastoma[J].Comput Assist Tomogr,2017,41(6):898~903. [6] Sade R,Kantarci M,Ogul H,et al.Differentiation between hepatic alveolar echinococcosis and primary hepatic malignancy with diffusion-weighted magnetic resonance imaging[J].Diagn Interv Imaging,2018,99(3):169~177. [7] 肖安岭,王海涛,张芃芃,等.磁共振动态增强联合弥散加权成像对原发性肝癌的诊断及其临床价值研究[J].临床和实验医学杂志,2018,270(14):74~77. [8] 陈旭东,王倩倩,陈巧巧.血清GP73、AFP、AFU检测对AFP低水平原发性肝癌的诊断价值[J].浙江医学,2018,40(16):67~69. [9] 王晓燕.联合检测血清GP73、AFP及AFP-L3在原发性肝癌中的诊断价值[J].标记免疫分析与临床,2017,24(1):64~66.
2020, Vol. 26 
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