Abstract：Objective: To investigate the effects of human cytomegalovirus (HCMV) infection on glucose metabolism, C-peptide and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). Methods: 154 patients with T2DM admitted to the hospital during the period from February 2016 to February 2018 were included in the T2DM group. 50 healthy adults were included in the control group. The HCMV-DNA viral load, fasting plasma Glucose (FPG), C-peptide (C-P), fasting insulin (Fins), insulin sensitivity index (ISI) and T lymphocyte subsets in all subjects were determined and analyzed. Results: The positive rates of HCMV-DNA in the T2DM group and the control group were 50.64% and 26.00%, respectively. The HCMV-DNA load in the T2DM group was significantly higher than that in the control group (P<0.05). The FPG, ratio of CD4+ lymphocytes and CD4+/CD8+ ratio were increased, the Fins, CP, ISI and ratio of CD8+ T lymphocytes were decreased in the T2DM group, compared with the control group (P<0.05). The increase or increase of each index in HCMV-DNA positive patients was significantly greater than that in HCMV-DNA negative patients (P<0.05). Conclusion: HCMV infection can cause abnormal glucose metabolism in patients with T2DM, reduce insulin sensitivity, aggravate immune imbalance, and promote the progression of the disease.
白耀博, 时艳, 刘伟. 人巨细胞病毒感染对2型糖尿病患者糖代谢C肽及胰岛素敏感性的影响[J]. 河北医学, 2020, 26(2): 252-254.
BAI Yaobo, SHI Yan, LIU Wei. Effects of Human Cytomegalovirus Infection on Glucose Metabolism C-peptide and Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus. HeBei Med, 2020, 26(2): 252-254.
[1] 徐玲,朱莉莉,叶黎离,等.人巨细胞病毒感染婴儿γδT、Treg细胞和相关细胞因子的表达及临床意义[J].中国当代儿科杂志,2018,5(3):204~208. [2] 周玉洁,张亚,徐秀兰,等.无偿献血人群人疱疹病毒8型和巨细胞病毒及细小病毒B19感染流行情况调查[J].中华医院感染学杂志,2017,27(3):514~517. [3] 郭丽丽,许红梅.人巨细胞病毒感染的流行病学研究进展[J].山东医药,2017,57(12):1131~1133. [4] Miotto Noelle, Mendes Leandro Cesar, Zanaga Leticia Pisoni,et al. All-oral direct antiviral treatment for hepatitis C chronic infection in a real-life cohort: The role of cirrhosis and comorbidities in treatment response[J]. Plos One,2017,13(7):41~42. [5] Yoneda S , Imagawa A , Fukui K , et al. A histological study of fulminant type 1 diabetes mellitus related to human cytomegalovirus reactivation[J]. The Journal of Clinical Endocrinology & Metabolism, 2017,5(10):55~57. [6] Yamaguchi A,Oh-Ishi T,Arai T,et al.Screening for seemingly healthy newborns with congenital cytomegalovirus infection by quantitative real-time polymerase chain reaction using newborn urine:an observational study[J].Bmj Open,2017,7(1):e013810. [7] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中国糖尿病杂志,2014,30(8):893~942. [8] Fernanda Langellotto, Maria Fiorentino, Elena De Felice,等. Expression of meis and hoxa11 in dipnoan and teleost fins provides new insights into the evolution of vertebrate appendages[J]. Evodevo, 2018, 9(1):44~45. [9] 王娜.2型糖尿病患者微生物感染与动脉粥样硬化相关性分析[J].糖尿病新世界,2018,21(17):75~76. [10] Lilleri D, Zelini P, Fornara C, et al. Human cytomegalovirus (HCMV)-specific T-cell but not neutralizing or ELISA IgG antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients[J]. Journal of Medical Virology, 2018, 90(10):1620~1628.
2020, Vol. 26 
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