Curative Effect of Pefloxacin Combined with Minocycline Hydrochloride on Periodontitis and the Influences on Early Periodontal Indexes and Osteocalcin Level in Gingival Crevicular Fluid
JIANG Tianjiao, WANG Xin, MA Nan
The Second Affiliated Hospital of Jinzhou Medical University, Liaoning Jinzhou 121000, China
摘要目的:探究牙周炎患者应用培氟沙星联合盐酸米诺环素治疗疗效。方法:选取2016年7月至2019年7月我院收治90例牙周炎患者为对象,采用随机数字表法分为单一用药组与联合用药组,每组均为45例患者,分别应用盐酸米诺环素与培氟沙星联合盐酸米诺环素治疗。比较两组患者治疗效果,治疗前后早期牙周指标,龈沟液相关指标水平差异,不良反应发生率以及复发率。结果:联合用药组患者治疗总有效率高于单一用药组,差异比较具有统计学意义(93.33% VS 75.56%,P<0.05);两组患者治疗后牙周袋深度、菌斑指数、临床附着丧失以及牙龈指数较治疗前显著改善(P<0.05),联合用药组患者治疗后上述早期牙周指标均显著低于单一用药组患者(P<0.05);两组患者治疗后龈沟液相关指标如IL-1β、sICAM-1、骨钙素、MCP-1与治疗前比较均下降,差异比较具有统计学意义(P<0.05),联合用药组患者各项龈沟液指标均显著低于单一用药组(P<0.05);联合用药组患者不良反应发生率与复发率均低于单一用药组,不良反应发生率差异没有统计学意义(17.78% VS 28.89%,P>0.05),复发率差异比较具有统计学意义(2.22% VS 20.00%,P<0.05)。结论:牙周炎应用培氟沙星联合盐酸米诺环素治疗效果显著,可以明显改善早期牙周指标和龈沟液中骨钙素水平,安全性好。
Abstract：Objective: To explore curative effect of pefloxacin combined with minocycline hydrochloride on periodontitis patients. Methods: During the period from July 2016 to July 2019, 90 periodontitis admitted to the hospital were enrolled as objects. They were divided into single medication group and combination medication group according to random number table method, 45 cases in each group. The two groups were treated with minocycline hydrochlorid or pefloxacin combined with minocycline hydrochloride, respectively. The curative effect, changes in early periodontal indexes before and after treatment and level of gingival crevicular fluid (GCF) related indexes, incidence of adverse reactions and recurrence rate were compared between the two groups. Results: The total response rate of treatment in combination medication group was higher than that in single medication group (93.33% vs75.56%, P<0.05). After treatment, depth of periodontal pocket, plaque index, clinical attachment loss and gingival index in both groups were significantly improved (P<0.05). The above early periodontal indexes in combination medication group were significantly lower than those in single medication group (P<0.05). After treatment, GCF related indexes such as IL-1β, sICAM-1, osteocalcin and MCP-1 in both groups were decreased (P<0.05). The all GCF indexes in combination medication group were significantly lower than those in single medication group (P<0.05. The incidence of adverse reactions and recurrence rate in combination medication group were lower than those in single medication group. There was no significant difference in incidence of adverse reactions between the two groups (17.78% vs28.89%, P>0.05), while there were significant differences in recurrence rate (2.22% vs20.00%, P<0.05). Conclusion: The curative effect of pefloxacin combined with minocycline hydrochloride is significant on periodontitis, which can significantly improve levels of early periodontal indexes and osteocalcin in GCF. And safety is good.
蒋天娇, 王鑫, 马楠. 培氟沙星联合盐酸米诺环素治疗牙周炎疗效及对早期牙周指标和龈沟液中骨钙素水平的影响[J]. 河北医学, 2020, 26(2): 230-234.
JIANG Tianjiao, WANG Xin, MA Nan. Curative Effect of Pefloxacin Combined with Minocycline Hydrochloride on Periodontitis and the Influences on Early Periodontal Indexes and Osteocalcin Level in Gingival Crevicular Fluid. HeBei Med, 2020, 26(2): 230-234.
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2020, Vol. 26 
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