Abstract：Objective: To explore the diagnostic value of dynamic contrast-enhanced magnetic resonance imaging (MRI) combined with serum CA15-3 and carcinoembryonic antigen (CEA) for breast cancer. Methods: 80 patients with breast cancer admitted to the hospital from January 2018 to February 2019 were included in the breast cancer group. 50 patients with benign breast tumors were selected and included in the benign group, respectively. All patients underwent dynamic contrast-enhanced MRI. Serum CA15-3 and CEA levels were detected. The differences in serological indicators among groups and the value of the indicators alone or combined diagnosis for breast cancer were analyzed. Results: MRI findings of malignant breast lesions showed unclear boundaries with surrounding tissues, irregular margins or burrs, and inhomogeneous enhancement. Findings of benign breast lesions showed masses with clear boundaries with surrounding tissues and smooth edge, round or lobulated shape, and homogeneous enhancement of most lesions. Levels of CA15-3 and CEA in the breast cancer group were significantly higher than those in the benign group (P<0.05). For alone diagnosis, the diagnostic sensitivity and accuracy of CEA were the lowest while diagnostic sensitivity and accuracy of MRI were the highest. The diagnostic sensitivity of MRI combined with CA15-3 and CEA was significantly higher than that of MRI, serum CA15-3 or CEA alone (P<0.05), while the specificity was lower than the other three methods. Conclusion: Dynamic contrast-enhanced MRI combined with serum CA15-3 and CEA can improve the diagnostic sensitivity of breast cancer, which is of value for the early diagnosis of breast cancer.
李月梅, 仲维秀, 杨丽萍. MRI动态增强成像联合血清CA15-3 CEA对乳腺癌的诊断价值[J]. 河北医学, 2020, 26(2): 218-221.
LI Yuemei, ZHONG Weixiu, YANG Liping. Diagnosis the Value of Dynamic Contrast-enhanced MRI Combined with Serum CA15-3 and CEA on Breast Cancer. HeBei Med, 2020, 26(2): 218-221.
[1] 庄丽,王慧明,宋法亮,等.高频超声与X线钼靶对早期乳腺癌的诊断价值[J].实用放射学杂志,2017,33(7):15~17. [2] Sanabria S J,Goksel,Orcun,Martini,Katharina,et al.Breast-density assessment with hand-held ultrasound:a novel biomarker to assess breast cancer risk and to tailor screening[J].European Radiology,2018,28(8):1~11. [3] Radovic,Niko,Ivanac,Gordana,Divjak,Eugen,et al.Evaluation of breast cancer morphology using diffusion-weighted and dynamic contrast-enhanced MRI:intermethod and interobserver agreement[J].Journal of Magnetic Resonance Imaging,2018,5(8):225~227. [4] Wang W,Xu,Xiaoqin,Tian,Baoguo,et al.The diagnostic value of serum tumor markers CEA,CA19-9,CA125,CA15-3,and TPS in metastatic breast cancer[J].Clinica Chimica Acta,2017,11(47):51~55. [5] 阳君.钼靶和超声及MRI对乳腺癌的诊断价值多中心研究及卫生经济学评价[J].放射学实践,2018,15(6):579~581. [6] 张亚平,董光,聂家秋,等.MRI对动态增强时间-信号曲线呈平台型乳腺纤维腺瘤及乳腺癌的鉴别诊断[J].医学研究生学报,2017,30(2):177~180. [7] Grimm,Lars J,Zhang,Jing,Baker,Jay A,et al.Relationships between MRI breast imaging-reporting and data system(BI-RADS) lexicon descriptors and breast cancer molecular subtypes:internal enhancement is associated with luminal B subtype[J].Breast Journal,2017,9(22):15~19. [8] 刘新唐,李玉柱,张海军.三维超声与MRI联合血清CA15-3、CEA诊断老年乳腺癌[J].现代肿瘤医学,2018,26(21):111~114. [9] 庹有林.乳腺超声光散射成像联合血清CA15-3、CEA检测在乳腺肿瘤中的诊断价值[J].中国医药导报,2017,14(26):90~93.
2020, Vol. 26 
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