结直肠癌组织中核运转蛋白KPNA2的表达及其与结直肠癌临床病理特征之间的关系

doi:10.3969/j.issn.1006-6233.2020.02.006

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摘要 目的:探究结直肠癌组织中核运转蛋白KPNA2的表达及其与结直肠癌临床病理特征之间的关系。方法:选取我院2017年1月至2019年3月收治的结直肠癌患者92例,设为结直肠癌组,选取同期体检的健康人92例作为正常对照组,收集两组受试对象的样本,进行免疫组化分析,对所有样本进行KPNA2表达的计算,比较两组患者KPNA2表达情况,比较结直肠癌组中不同病理特征患者间KPNA2表达的差异情况,并进行Logistic回归分析。结果:结直肠癌组患者KPNA2表达率为72.83%,显著高于正常对照组;KPNA2的表达在不同肿瘤大小、分化程度、T分期、N分期、M分期的患者中存在显著差异;肿瘤大小、T分期、N分期、M分期与KPNA2表达呈正相关,分化程度与KPNA2表达呈负相关。以上均有P<0.05。结论:结直肠癌患者组织中KPNA2表达明显上调,其高表达与患者肿瘤大小、肿瘤分化以及分期具有密切关联,对判断患者肿瘤发生发展具有一定的诊断价值。

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	马春艳

关键词 ：结肠癌, 直肠癌, 核运转蛋白KPNA2, 病理学

Abstract：Objective: To investigate the expression of nuclear transporter protein KPNA2 in colorectal cancer and its relationship with clinicopathological features of colorectal cancer. Methods: 92 patients with colorectal cancer admitted to our hospital from January 2017 to March 2019 were selected as colorectal cancer group. Ninety-two healthy people who had physical examination at the same time were selected as normal control group. Samples of two groups of subjects were collected for immunohistochemical analysis, and the expression of KPNA2 was calculated for all samples. The expression of KPNA2 was compared between the two groups. The difference of KPNA2 expression among patients with different pathological characteristics in colorectal cancer group was compared and logistic regression analysis was performed. Results: The expression rate of KPNA2 in colorectal cancer group was 72.83%, which was higher than that in normal control group. The expression of KPNA2 was different in patients with different tumor size, differentiation degree, T stage, N stage and M stage. Tumor size, T stage, N stage and M stage were positively correlated with KPNA2 expression, while differentiation degree was negatively correlated with KPNA2 expression. All the above were P<0.05. Conclusion: The expression of KPNA2 in colorectal cancer tissues is significantly up-regulated. The high expression of KPNA2 is closely related to the size, differentiation and staging of colorectal cancer. It has certain diagnostic value in judging the occurrence and development of colorectal cancer.

Key words： Colon cancer Rectal cancer Nuclear transporter protein KPNA2 Pathology

基金资助:河北省承德市科学技术研究与发展计划项目,(编号:20122183)

引用本文:

马春艳. 结直肠癌组织中核运转蛋白KPNA2的表达及其与结直肠癌临床病理特征之间的关系[J]. 河北医学, 2020, 26(2): 197-201.
MA Chunyan. Expression of Nuclear Transporter Protein KPNA2 in Colorectal Cancer Tissues and Its Relationship with Clinicopathological Features of Colorectal Cancer. HeBei Med, 2020, 26(2): 197-201.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2020.02.006 或 http://www.hbyxzzs.cn/CN/Y2020/V26/I2/197

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