摘要目的:观察三种不同药物(坦索罗辛、硝苯地平、消旋山莨菪碱)治疗输尿管下段结石的临床疗效。方法:采用简单随机分组方法,选取我院2016年1月至2018年12月我院90例输尿管下段结石患者,分为坦索罗辛组、硝苯地平组、消旋山莨菪碱组及对照组,分别为22例、23例、22例、23例。四组患者均需要大量饮水保证每日总尿量>2000mL,其中坦索罗辛组、硝苯地平组、消旋山莨菪碱组给药方式为0.4mg po qd、10 mg po tid、10mg po tid,对照组则不给予药物干预,疗程为2周。观察各组患者治疗效果,比较排石直径、排石时间和残留结石直径,记录不良反应的发生情况。结果:总有效率:坦索罗辛组>消旋山莨菪碱组>硝苯地平组>对照组(P<0.05);排石大小:坦索罗辛组>消旋山莨菪碱组>硝苯地平组>对照组(P<0.05);排石时间:坦索罗辛组<硝苯地平组<消旋山莨菪碱组<对照组(P<0.05),硝苯地平组、消旋山莨菪碱组比较提示差异无统计学意义(P>0.05);残留结石大小:坦索罗辛组<硝苯地平组<消旋山莨菪碱组<对照组(P<0.05);治疗期间四组患者未出现明显不良反应。结论:坦索罗辛治疗输尿管下段结石患者方面较硝苯地平、消旋山莨菪碱具有更佳的临床疗效,硝苯地平与消旋山莨菪治疗效果相似,三组安全性较好。
Abstract：Objective: To observe the clinical efficacy of three different drugs (tamsulosin, nifedipine and racemic anisodamine) in the treatment of lower ureteral calculi. Methods: 90 patients with lower ureteral calculi in our hospital from January 2016 to December 2018 were randomly divided into tamsulosin group, nifedipine group, racemic anisodamine group and control group, with 22 cases, 23 cases, 22 cases and 23 cases respectively. All four groups needed a large amount of water to ensure the daily total urine volume > 2000 ml, of which tamsulosin group. Group B, nifedipine group and racemic anisodamine group were given 0.4 mg po qd, 10 mg potid and 10 mg po tid, while blank control group was not given drug intervention for 2 weeks. To observe and compare the clinical efficacy, the size of stone removal, the time of stone removal, the size of residual stones and adverse reactions of each group. Results: The total effective rate was tamsulosin group > racemic anisodamine group > nifedipine group > control group (P<0.05); lithotripsy size was tamsulosin group > racemic anisodamine group > nifedipine group > control group (P<0.05); lithotripsy time was tamsulosin group < nifedipine group < racemic anisodamine group < control group (P<0.05). There was no significant difference between nifedipine group and racemic anisodamine group (P>0.05); residual stone size of tamsulosin group < nifedipine group < racemic anisodamine group < control group (P<0.05); no significant adverse reactions occurred in the four groups during the experiment. Conclusion: Tamsulosin has better clinical efficacy than nifedipine and racemic anisodamine in the treatment of lower ureteral calculi. Nifedipine and racemic anisodamine have similar therapeutic effects, and the three groups have better safety.
曹雪, 李鸿录, 佟晓姝. 三种不同药物治疗输尿管下段结石的临床疗效观察[J]. 河北医学, 2020, 26(1): 166-168.
CAO Xue, LI Honglu, TONG Xiaoshu. Clinical Observation of Three Different Drugs for Treatment of Lower Ureteral Calculi. HeBei Med, 2020, 26(1): 166-168.
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2020, Vol. 26 
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