Abstract：Objective: To investigate the serum levels of HIF-1α and VEGF in patients with craniocerebral injury and their relationship with severity degree and prognosis. Methods: 198 patients with craniocerebral injury (study group) and 70 cases of health examinees (control group) in Panzhihua Central Hospital from February 2017 to December 2018 were selected. The study group was re-divided into four subgroups according to the Glasgow Coma Scale (GCS) and post-treatment daily living ability, namely mild group (n=62), moderate group (n=76), severe group (n=60), good prognosis group (n=140) and poor prognosis group (n=58). The levels of HIF-1α and VEGF were detected by enzyme-linked immunosorbent assay (ELISA) on the 1st, 3rd and 7th day after admission, and their relationship with prognosis were compared. Results: The serum levels of HIF-1a and VEGF in the study group were significantly higher than those in the control group (P<0.05). The levels of serum HIF-1α and VEGF on the 1st, 3rd and 7th day after admission ranking in a descending order severe group, moderate group and mild group (P<0.001). The serum levels of HIF-1α and VEGF in the poor prognosis group were significantly higher than those in the prognosis group (P<0.001). Logistic regression analysis showed moderate degree (OR=3.39, 95%CI: 2.66~4.32), severe degree (OR=5.19, 95%CI: 3.89~6.92), serum HIF-1α≥62.24ng/ml (OR=3.48, 95%CI: 2.47~4.90), and VEGF≥160.91pg/ml (OR=4.67, 95%CI: 2.81~7.76) were risk factors for good prognosis in patients with craniocerebral injury. Conclusion: The levels of serum HIF-1 α and VEGF increased in patients with brain injury, and even higher in patients with poor prognosis. Therefore, the levels of serum HIF-1 α and VEGF have an important relationship with the prognosis of patients with brain injury.
戴领, 卜莉. 颅脑损伤患者血清HIF-1α VEGF水平及与损伤程度和预后的关系[J]. 河北医学, 2020, 26(1): 84-87.
DAI Ling, et al. Serum Levels of HIF-1α and VEGF in Patients with Craniocerebral Injury and Their Relationship with Severity Degree and Prognosis. HeBei Med, 2020, 26(1): 84-87.
[1] 马锦华,高静,王珊珊,等.西安市2025例颅脑损伤住院患者临床及流行病学特点[J].创伤外科杂志,2017,19(6):411~416. [2] 廖吉连,程世翔,衣泰龙,等.基于转录组学的创伤性颅脑损伤基因表达变化[J].中华神经外科杂志,2017,33(1):72~77. [3] Wang F, Wang K, Xu W, et al. SIRT5 desuccinylates and activates pyruvate kinase m2 to block macrophage IL-1β production and to prevent DSS-induced colitis in mice[J]. Cell Rep, 2017, 19(11):2331~2344. [4] Wang X, Freire AV, Schermann G, et al. YAP/TAZ orchestrate VEGF signaling during developmental angiogenesis[J]. Dev Cell, 2017, 42(5):462~478. [5] 梁鑫,李玉雄,张凌,等.颅脑损伤后脑脊液NSES100β水平动态变化与颅内压异常的关系研究[J].河北医学,2017,23(12):2072~2076. [6] Kimura A, Tanaka N. Reverse shock index multiplied by glasgow coma scale score (rSIG) is a simple measure with high discriminant ability for mortality risk in trauma patients: an analysis of the Japan Trauma Data Bank[J]. Crit Care, 2018, 22(1):87. [7] Duan C, Chen K, Yang G, et al. HIF-1αregulates Cx40-dependent vasodilatation following hemorrhagic shock in rats[J]. Am Transl Res, 2017, 9(3):1277~1286. [8] Jin H, Li D, Wang X, et al. VEGF and VEGFB play balancing roles in adipose differentiation, gene expression and function[J]. Endocrinology, 2018, 159(5):2036~2049. [9] Byard RW, Donkin J, Vink R. The forensic implications of amphetamine intoxication in cases of inflicted blunt craniocerebral trauma[J].Forensic Sci, 2017, 63(1):151~153.
2020, Vol. 26 
冀公网安备13080202000786号