Abstract：Objective: To investigate the serum levels of HIF-1α and VEGF in patients with craniocerebral injury and their relationship with severity degree and prognosis. Methods: 198 patients with craniocerebral injury (study group) and 70 cases of health examinees (control group) in Panzhihua Central Hospital from February 2017 to December 2018 were selected. The study group was re-divided into four subgroups according to the Glasgow Coma Scale (GCS) and post-treatment daily living ability, namely mild group (n=62), moderate group (n=76), severe group (n=60), good prognosis group (n=140) and poor prognosis group (n=58). The levels of HIF-1α and VEGF were detected by enzyme-linked immunosorbent assay (ELISA) on the 1st, 3rd and 7th day after admission, and their relationship with prognosis were compared. Results: The serum levels of HIF-1a and VEGF in the study group were significantly higher than those in the control group (P<0.05). The levels of serum HIF-1α and VEGF on the 1st, 3rd and 7th day after admission ranking in a descending order severe group, moderate group and mild group (P<0.001). The serum levels of HIF-1α and VEGF in the poor prognosis group were significantly higher than those in the prognosis group (P<0.001). Logistic regression analysis showed moderate degree (OR=3.39, 95%CI: 2.66~4.32), severe degree (OR=5.19, 95%CI: 3.89~6.92), serum HIF-1α≥62.24ng/ml (OR=3.48, 95%CI: 2.47~4.90), and VEGF≥160.91pg/ml (OR=4.67, 95%CI: 2.81~7.76) were risk factors for good prognosis in patients with craniocerebral injury. Conclusion: The levels of serum HIF-1 α and VEGF increased in patients with brain injury, and even higher in patients with poor prognosis. Therefore, the levels of serum HIF-1 α and VEGF have an important relationship with the prognosis of patients with brain injury.
戴领, 卜莉. 颅脑损伤患者血清HIF-1α VEGF水平及与损伤程度和预后的关系[J]. 河北医学, 2020, 26(1): 84-87.
DAI Ling, et al. Serum Levels of HIF-1α and VEGF in Patients with Craniocerebral Injury and Their Relationship with Severity Degree and Prognosis. HeBei Med, 2020, 26(1): 84-87.
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2020, Vol. 26 
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