Abstract：Objective: To investigate the relationship between the ratio of apolipoprotein B/A1 and the level of homocysteine and coronary heart disease (CAD) in the elderly. Methods: From January 2017 to June 2019, 81 patients in Huangshan people's hospital were selected for coronary angiography. 36 patients in group A were 30% < 70% of the degree of coronary stenosis, 45 patients in group B were ≥ 75% of the degree of coronary stenosis, and 30 patients in the control group were negative in the same period. The levels of serum Hcy, apoB, ApoA1, HDL-C and LDL-C were measured. The ratio of serum apoB / A1 and the relationship between serum Hcy and senile coronary heart disease were analyzed. Results: The levels of aopa1, apoB, apoB / A1, Hcy and LDL-C in group A and group B were significantly higher than those in the control group (P < 0.05), and the levels increased with the aggravation of patients' condition; the levels of HDL-C in group A and group B were significantly lower than those in the control group (P<0.05). ApoB / A1 were the risk factor of coronary artery stenosis (P<0.01). Conclusion: Apolipoprotein B/ A1 and homocysteine show a rising trend with the increase of the condition of patients with coronary heart disease, and the level of AopB/ A1 of great significance to the prediction of elderly patients with coronary heart disease. And is worthy of clinical use.
[1] Nelson C, Goel A, Butterworth A, et al. Association analyses based on false discovery rate implicate new loci for coronary artery disease[J]. Nature Genetics, 2017, 49(9):1385. [2] 崔园园,赵锡海,蔡剑鸣.动脉粥样硬化斑块出血形成机制及其影响因素[J].中华老年心脑血管病杂志,2017,19(3):316~318. [3] 段平,尹德录.高同型半胱氨酸代谢酶基因多态性与冠心病发病关系的研究进展[J].中国循证心血管医学杂志,2017,9(2):249~251. [4] Tani S, Yagi, Tsukasa, Atsumi, et al. Relation between low-density lipoprotein cholesterol/apolipoprotein B ratio and triglyceride-rich lipoproteins in patients with coronary artery disease and type 2 diabetes mellitus: a cross-sectional study[J]. Cardiovascular Diabetology, 2017, 16(1):123. [5] 赵晓萌,高雷,刘勇.血清同型半胱氨酸与超敏肌钙蛋白T联合检测在冠状动脉粥样硬化性心脏病诊断中的应用[J].中国医科大学学报,2017,46(1):59~61. [6] 冯高科,汪小丁,陈晶晶,等.冠心病危险因素与冠脉病变程度的相关分析[J].中国医师杂志,2018,20(1):72~75. [7] 刘向阳,唐良秋,范文茂,等.不同血压昼夜节律冠心病患者血浆同型半胱氨酸、血清脂蛋白相关磷脂酶A2水平变化及其与冠状动脉狭窄程度的关系研究[J].实用心脑肺血管病杂志,2019,27(1):30~35. [8] 宋艳东,陶英,王苏,等.冠心病患者同型半胱氨酸、血尿酸水平与冠脉病变的相关性[J].中华急诊医学杂志,2017,26(4):430~433. [9] 刘艳红,刘迎午.中性粒细胞明胶酶相关载脂蛋白在冠心病风险预测中的价值[J].心血管病学进展,2017,38(2):193~196. [10] 刘佟,史菲,丁振江,等.单核细胞/高密度脂蛋白比值与炎性脂肪因子水平及冠动脉疾病严重程度的相关性[J].中国动脉硬化杂志,2018,26(11):1159~1164. [11] 陈严,吕晶,董艾艾,等.载脂蛋白B/载脂蛋白A1比值在糖尿病合并冠心病患者冠状动脉病变评估中的作用[J].心脑血管病防治,2018,18(5):376~378. [12] 卢群,张俊,田刚,等.各血脂指标与高密度脂蛋白胆固醇比值对冠心病的诊断价值[J].山西医科大学学报,2017,48(9):883~886.
2020, Vol. 26 
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